Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol.
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DOI: 10.1021/acs.jnatprod.2c00434
Abstract: Hypothemycin, an epoxide derivative of (5Z)-7-oxozeaenol, was used in the semisynthesis of a series of C8-C9 diol derivatives, with many inhibiting TAK1 at submicromolar concentrations. A step-economical approach was chosen, whereby nonselective reactions functionalized the… read more here.
Keywords: semisynthesis; hypothemycin analogues; hypothemycin; targeting diol ... See more keywords