Biosynthesis of tetrahydropapaverine and semisynthesis of papaverine in yeast
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205848119
Abstract: Significance We report the de novo microbial biosynthesis of (S)-tetrahydropapaverine (THP) and the semisynthesis of papaverine using microbially biosynthesized THP. We used protein engineering to develop variants of two enzymes with improved nonnative activity on… read more here.
Keywords: papaverine; semisynthesis papaverine; biosynthesis; biosynthesis tetrahydropapaverine ... See more keywords