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Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205848119
Abstract: Significance We report the de novo microbial biosynthesis of (S)-tetrahydropapaverine (THP) and the semisynthesis of papaverine using microbially biosynthesized THP. We used protein engineering to develop variants of two enzymes with improved nonnative activity on…
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Keywords:
papaverine;
semisynthesis papaverine;
biosynthesis;
biosynthesis tetrahydropapaverine ... See more keywords