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   Articles with "senescence" as a keyword



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Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.

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recommendations! Published in 2021 at "Molecular oncology"

DOI: 10.1002/1878-0261.13128

Abstract: Uveal melanoma (UM) is the most common intraocular tumor in adults. Recurrent mutations in BRCA1-associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a mutually exclusive pattern in UM, but the underlying… read more here.

Keywords: melanoma; sf3b1; bap1; senescence ... See more keywords
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A new function for the serine protease HtrA2 in controlling radiation‐induced senescence in cancer cells

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13187

Abstract: Radiation therapy can induce cellular senescence in cancer cells, leading to short‐term tumor growth arrest but increased long‐term recurrence. To better understand the molecular mechanisms involved, we developed a model of radiation‐induced senescence in cultured… read more here.

Keywords: htra2; senescence; radiation; radiation induced ... See more keywords
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Targeting senescence as an anticancer therapy

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13312

Abstract: Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate… read more here.

Keywords: one two; senescence; senescent cells; anticancer ... See more keywords
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Senescence is delayed when ramie (Boehmeria nivea L.) is transformed with the isopentyl transferase (ipt) gene under control of the SAG12 promoter

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12191

Abstract: Ramie is an economically important industrial fiber crop widely planted in China, India, and other Southeast Asian and Pacific Rim countries. It plays an important role in China's economy, where ramie farming, industry, and trade… read more here.

Keywords: senescence; transferase ipt; ipt gene; isopentyl transferase ... See more keywords
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SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485

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recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12895

Abstract: Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported to modulate vascular… read more here.

Keywords: sirt1; ampk ser485; senescence; ampk ... See more keywords
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Midazolam alleviates cellular senescence in SH‐SY5Y neuronal cells in Alzheimer's disease

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recommendations! Published in 2022 at "Brain and Behavior"

DOI: 10.1002/brb3.2822

Abstract: Alzheimer's disease (AD) impacts the daily life of aging people. Oligomerized amyloid β (Aβ)‐associated neuronal senescence is involved in the pathological mechanism of AD. Blockage of neuronal senescence has been considered an important strategy for… read more here.

Keywords: midazolam alleviates; senescence; alzheimer disease; alleviates cellular ... See more keywords
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Expansion of adipose tissue‐derived stromal cells at “physiologic” hypoxia attenuates replicative senescence

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recommendations! Published in 2017 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.3267

Abstract: Multipotent mesenchymal stromal cells are considered as a perspective tool in cell therapy and regenerative medicine. Unfortunately, autologous cell therapy does not always provide positive outcomes in elder donors, perhaps as a result of the… read more here.

Keywords: replicative senescence; stromal cells; senescence; adipose tissue ... See more keywords
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Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200364

Abstract: Cellular senescence is a stable cell cycle arrest state that can be triggered by a wide range of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is thought to contribute to… read more here.

Keywords: advances strategies; senescence; detection; senescent cells ... See more keywords
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Hyaluronan‐binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells

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recommendations! Published in 2020 at "Cell Biology International"

DOI: 10.1002/cbin.11326

Abstract: Hyaluronan‐binding protein 1 (HABP1), a multi‐compartmental, multi‐functional protein has a wide range of functions, which can be attributed to its ability to associate with a variety of cellular ligands. Earlier we have reported that HABP1… read more here.

Keywords: protein; senescence; hyaluronan binding; habp1 overexpression ... See more keywords
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Metformin attenuates lipopolysaccharide‐induced epithelial cell senescence by activating autophagy

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recommendations! Published in 2020 at "Cell Biology International"

DOI: 10.1002/cbin.11536

Abstract: Acute lung injury (ALI) is a life‐threatening medical condition with higher mortality and morbidity in elderly patients. Recently, metformin, a drug commonly used to lower blood glucose in type 2 diabetes patients, has been shown… read more here.

Keywords: epithelial cell; cell senescence; atg5; senescence ... See more keywords
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Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs

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recommendations! Published in 2022 at "Drug Development Research"

DOI: 10.1002/ddr.21937

Abstract: Dendrobine has potential advantages in suppressing atherosclerosis (AS). FK506‐binding protein 1A (FKBP1A) is implicated in the regulation of autophagy, inflammation, and apoptosis. To reveal the mechanism by which dendrobine inhibits AS by modulating autophagy, oxidative… read more here.

Keywords: dendrobine; apoptosis; oxidative stress; senescence ... See more keywords