LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "senescence" as a keyword



Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.

Sign Up to like & get
recommendations! Published in 2021 at "Molecular oncology"

DOI: 10.1002/1878-0261.13128

Abstract: Uveal melanoma (UM) is the most common intraocular tumor in adults. Recurrent mutations in BRCA1-associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a mutually exclusive pattern in UM, but the underlying… read more here.

Keywords: melanoma; sf3b1; bap1; senescence ... See more keywords

A new function for the serine protease HtrA2 in controlling radiation‐induced senescence in cancer cells

Sign Up to like & get
recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13187

Abstract: Radiation therapy can induce cellular senescence in cancer cells, leading to short‐term tumor growth arrest but increased long‐term recurrence. To better understand the molecular mechanisms involved, we developed a model of radiation‐induced senescence in cultured… read more here.

Keywords: htra2; senescence; radiation; radiation induced ... See more keywords

Targeting senescence as an anticancer therapy

Sign Up to like & get
recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13312

Abstract: Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate… read more here.

Keywords: one two; senescence; senescent cells; anticancer ... See more keywords

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Sign Up to like & get
recommendations! Published in 2025 at "Molecular Oncology"

DOI: 10.1002/1878-0261.70021

Abstract: Transforming growth factor‐β (TGF‐β) signaling and cellular senescence are key hallmarks of hepatocellular carcinoma (HCC) pathogenesis. Despite provoking senescence‐associated growth arrest in epithelial HCC cells, elevated TGF‐β activity paradoxically correlates with increased aggressiveness and poor… read more here.

Keywords: senescence; hepatocellular carcinoma; tgf; epithelial hcc ... See more keywords

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Sign Up to like & get
recommendations! Published in 2025 at "Molecular Oncology"

DOI: 10.1002/1878-0261.70039

Abstract: Cellular senescence has recently been recognized as a significant contributor to the poor prognosis of glioblastoma, one of the most aggressive brain tumors. Consequently, effectively eliminating senescent glioblastoma cells could benefit patients. Human ADP/ATP translocases… read more here.

Keywords: senescence; cellular senescence; glioblastoma; isoform ... See more keywords

Senescence is delayed when ramie (Boehmeria nivea L.) is transformed with the isopentyl transferase (ipt) gene under control of the SAG12 promoter

Sign Up to like & get
recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12191

Abstract: Ramie is an economically important industrial fiber crop widely planted in China, India, and other Southeast Asian and Pacific Rim countries. It plays an important role in China's economy, where ramie farming, industry, and trade… read more here.

Keywords: senescence; transferase ipt; ipt gene; isopentyl transferase ... See more keywords

SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485

Sign Up to like & get
recommendations! Published in 2020 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12895

Abstract: Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported to modulate vascular… read more here.

Keywords: sirt1; ampk ser485; senescence; ampk ... See more keywords

Mesoporous Ternary Nanozymes with Anti‐Senescence and Anti‐Inflammation Activities for Atherosclerosis Management

Sign Up to like & get
recommendations! Published in 2024 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202313646

Abstract: Numerous anti‐inflammatory agents and corresponding therapeutic strategies have been explored for treating inflammation‐related atherosclerosis, which has struggled with compromised antiatherosclerotic efficacy due to the complex pathogenesis. The senescent endothelial cells participate fundamentally at all stages… read more here.

Keywords: senescence; anti inflammation; anti inflammatory; anti senescence ... See more keywords

Targeting MCH Neuroendocrine Circuit in Lateral Hypothalamus to Protect Against Skeletal Senescence

Sign Up to like & get
recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202309951

Abstract: Neuroendocrine regulation is essential for maintaining metabolic homeostasis. However, whether neuroendocrine pathway influence bone metabolism and skeletal senescence is unelucidated. Here, a central neuroendocrine circuit is identified that directly controls osteogenesis. Using virus based tracing,… read more here.

Keywords: senescence; lateral hypothalamus; neuroendocrine circuit; bone ... See more keywords

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging

Sign Up to like & get
recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202402168

Abstract: Cellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and contributes to poor cell therapy outcomes. Aging tissues are associated with extracellular… read more here.

Keywords: senescence; delays senescence; youth; senescence replicative ... See more keywords

Blockade of ZMIZ1‐GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage

Sign Up to like & get
recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202404311

Abstract: Susceptibility to cartilage degeneration increases in an age‐dependent manner and older cartilage exhibits increased catabolic factor expression leading to osteoarthritis (OA). While inhibition of cellular senescence can prevent age‐related diseases, the understanding of the regulators… read more here.

Keywords: senescence; zmiz1 gata4; cartilage; aged cartilage ... See more keywords