A candidate gene of Alzheimer diseases was mutated in senescence-accelerated mouse prone (SAMP) 8 mice.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.095
Abstract: The senescence-accelerated mouse prone (SAMP) 8 strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. We have found strong association of chromosome 12 locus with learning memory deficit (LMD) phenotype in… read more here.
Keywords: senescence accelerated; accelerated mouse; slc24a4; candidate gene ... See more keywords
Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2018.09.023
Abstract: Abstract This study investigated the effects of tempeh on the cognitive and antioxidant status in senescence-accelerated mouse prone 8 (SAMP8) mice. Six-month-old SAMP8 mice were divided into one control and three tempeh groups; the tempeh… read more here.
Keywords: senescence accelerated; expression; tempeh groups; modulating nrf2 ... See more keywords
Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver‐derived TNF‐α in senescence‐accelerated mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16171
Abstract: Although liver diseases, including non‐alcoholic steatohepatitis, are associated with skeletal muscle atrophy, the mechanism behind their association has not been fully elucidated. In this study, the effects of aging and non‐alcoholic steatohepatitis on the skeletal… read more here.
Keywords: liver; accelerated mice; senescence accelerated; muscle ... See more keywords
Expression of neurotransmitters, vasculogenesis markers and myosin heavy chain isoforms in the masseter muscle of senescence-accelerated mouse prone 8 mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of oral rehabilitation"
DOI: 10.1111/joor.13449
Abstract: BACKGROUND Learning and memory deficits and pathologic changes in the hippocampus caused by toothlessness and soft diet feeding are related to reduced masseter muscle (MM) function. OBJECTIVE Myosin heavy chain (MyHC) isoform expression in the… read more here.
Keywords: cgrp; senescence accelerated; expression; samr1 ... See more keywords
High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/5030475
Abstract: Alzheimer's Disease (AD) is the most common Neurodegenerative Disease (ND), primarily characterised by neuroinflammation, neuronal plaques of β-amyloid (Aβ), and neurofibrillary tangles of hyperphosphorylated tau. α-Synuclein (α-syn) and its heteroaggregates with Aβ and tau have… read more here.
Keywords: senescence accelerated; red blood; tau; brain ... See more keywords
The Establishment of a Mouse Model for Degenerative Kyphoscoliosis Based on Senescence-Accelerated Mouse Prone 8
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7378403
Abstract: Objective Degenerative kyphoscoliosis (DKS) is a complex spinal deformity associated with degeneration of bones, muscles, discs, and facet joints. The aim of this study was to establish an animal model of degenerative scoliosis that recapitulates… read more here.
Keywords: model degenerative; senescence accelerated; group; model ... See more keywords
Effects of electroacupuncture on DNA methylation of the TREM2 gene in senescence-accelerated mouse prone 8 mice
Sign Up to like & getrecommendations! Published in 2022 at "Acupuncture in Medicine"
DOI: 10.1177/09645284221077103
Abstract: Objective: To explore the mechanism by which electroacupuncture (EA) upregulates triggering receptor expressed on myeloid cells 2 (TREM2) protein in the hippocampus of Alzheimer’s disease (AD) model animals from the perspective of TREM2 DNA methylation.… read more here.
Keywords: methylation; senescence accelerated; trem2 gene; mice ... See more keywords
Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0240378
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease and is known to be the most common cause of dementia. We previously described the benefits of aromatherapy on the cognitive function of patients with AD utilizing… read more here.
Keywords: senescence accelerated; amyloid beta; accelerated mouse; mouse prone ... See more keywords
Sesamin suppresses aging phenotypes in adult muscular and nervous systems and intestines in a Drosophila senescence-accelerated model.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201902_17146
Abstract: OBJECTIVE Sesamin is a major lignan constituent of sesame and possesses various health-promoting effects. Previous studies have demonstrated that sesamin extends the lifespan of Drosophila and Caenorhabditis elegans and corrects oxidative damage-related tissue dysfunction in mammals. To understand… read more here.
Keywords: senescence accelerated; sesamin; aging effects; drosophila senescence ... See more keywords
Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.568423
Abstract: Background: Alzheimer’s disease (AD) is a fatal neurodegenerative disease characterized by progressive cognitive decline and memory loss. However, several therapeutic approaches have shown unsatisfactory outcomes in the clinical setting. Thus, developing alternative therapies for the… read more here.
Keywords: samp8 mice; brain; gut; senescence accelerated ... See more keywords
Effects of Turmeric Extract on Age-Related Skeletal Muscle Atrophy in Senescence-Accelerated Mice
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13040941
Abstract: Muscle atrophy is one of the main causes of sarcopenia—the age-related loss of skeletal muscle. In this study, we investigated the effect of turmeric (Curcuma longa) extract (TE) supplementation on age-related muscle atrophy in a… read more here.
Keywords: age related; senescence accelerated; muscle; muscle atrophy ... See more keywords