Identification of several senescence‐associated genes signature in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24555
Abstract: As one of the core aging processes, cellular senescence is associated with tumorigenesis, growth, and immune modulation in cancers. Nevertheless, the prognosis of senescence‐associated genes (SAGs) signature in head and neck squamous cell carcinoma (HNSCC)… read more here.
Keywords: head neck; associated genes; senescence; signature head ... See more keywords
Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12041
Abstract: Abstract A hallmark of senescence is the acquisition of an enhanced secretome comprising inflammatory mediators and tissue remodelling agents – the senescence‐associated secretory phenotype (SASP). Through the SASP, senescent cells are hypothesised to contribute to… read more here.
Keywords: methodology; secretory phenotype; senescence associated; senescence ... See more keywords
Relationship between circulating senescence-associated secretory phenotype levels and severity of type 2 diabetes-associated periodontitis: A cross-sectional study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of periodontology"
DOI: 10.1002/jper.22-0445
Abstract: BACKGROUND Senescence-associated secretory phenotype (SASP) has recently been found to drive comorbid diabetes and periodontitis by inducing a chronic, low-degree inflammatory state. Here, we sought to explore the relationship between circulating SASP and severity of… read more here.
Keywords: sasp; group; periodontitis; severity ... See more keywords
RT-qPCR Detection of Senescence-Associated Circular RNAs.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6670-7_7
Abstract: Primary cells that reach the end of their replicative potential, encounter sublethal stress, or experience the activation of certain oncogenes cease proliferation and enter a state of long-term growth arrest named senescence. The senescent process… read more here.
Keywords: associated circular; detection; senescence associated; qpcr detection ... See more keywords
Identification and Functional Analysis of Senescence-Associated Genes in Wheat.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7672-0_19
Abstract: Senescence is the final stage of leaf development. During this process, different macromolecules undergo degradation, and the resulting components are transported to developing and storage tissues of the plant. Senescence-associated genes (SAGs) play important roles… read more here.
Keywords: associated genes; senescence associated; analysis; senescence ... See more keywords
Cellular Identification and Quantification of Senescence-Associated β-Galactosidase Activity In Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8931-7_4
Abstract: Senescence-associated β-galactosidase (hereafter SA-β-gal) staining has now been employed for more than 20 years to identify the presence of senescent cells (Dimri et al., Proc Natl Acad Sci U S A 92:9363-9367, 1995). These cells, characterized… read more here.
Keywords: identification quantification; cellular identification; associated galactosidase; senescence associated ... See more keywords
Senescence-associated miR-34a and miR-126 in middle-aged Indians with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-019-00593-4
Abstract: Rapid urbanization and unhealthy dietary patterns critically increase the risk of type 2 diabetes (T2D) in middle-aged Indians. However, despite recent evidence of senescence-associated microRNAs (SA-miRNAs) in regulating complex pathways of ageing, their expressions in middle-aged… read more here.
Keywords: mir 126; senescence associated; mir 34a; middle aged ... See more keywords
Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-05140-8
Abstract: Human diploid fibroblasts (HDFs) cultured in vitro have limited capacity to proliferate after population doubling is repeated several times, and they enter into a state known as replicative senescence or cellular senescence. This study aimed… read more here.
Keywords: senescent hdfs; replicative senescence; senescence associated; senescence ... See more keywords
A rapid-response near-infrared fluorescent probe with a large Stokes shift for senescence-associated β-galactosidase activity detection and imaging of senescent cells
Sign Up to like & getrecommendations! Published in 2020 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108657
Abstract: Abstract Detection of senescence-associated β-galactosidase (SA-β-gal) activity at an increased lysosomal pH is one of the most reliable approaches for probing senescent cells. Herein, we developed a novel near-infrared fluorescent probe (KSL0401) for sensing SA-β-gal… read more here.
Keywords: detection; senescence associated; probe; senescent cells ... See more keywords
Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2020.111355
Abstract: Senescent cells are deeply involved in the induction of tissue damage and aging-related diseases. The identification of factors that eliminate senescent cells or inhibit the senescence-associated secretory phenotype (SASP) in these cells is necessary. Here,… read more here.
Keywords: secretory phenotype; senescence associated; senescent cells; associated secretory ... See more keywords
Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2017.11.005
Abstract: Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired… read more here.
Keywords: phenotype; senescence associated; senescent cells; lung diseases ... See more keywords