Inorganic nitrate alleviates the senescence-related decline in liver function
Sign Up to like & getrecommendations! Published in 2017 at "Science China Life Sciences"
DOI: 10.1007/s11427-017-9207-x
Abstract: Senescence-related decline in liver function is a common complication in the elderly that can lead to impaired health in older individuals. Dietary nitrate supplements have physiological and therapeutic effects on organ function by nitrate (NO3−)-nitrite… read more here.
Keywords: related decline; liver; nitrate; decline liver ... See more keywords
Stable Regulation of Senescence-Related Genes in Galactose-alpha1,3-galactose Epitope Knockout and Human Membrane Cofactor Protein hCD46 Pig.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.03.028
Abstract: BACKGROUND Pigs are considered suitable animal donor models for xenotransplantation. For successful organ transplantation, immune rejection must be overcome. Xenotransplantation has recently been successfully performed using galactose-alpha1,3-galactose epitopes knockout (GalTKO) and a human membrane cofactor… read more here.
Keywords: pig; hcd46; related genes; galtko hcd46 ... See more keywords
Investigating the role of senescence biomarkers in colorectal cancer heterogeneity by bulk and single-cell RNA sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-70300-1
Abstract: Colorectal cancer (CRC) is one of most common tumors worldwide, causing a prominent global health burden. Cell senescence is a complex physiological state, characterized by proliferation arrest. Here, we investigated the role of cellular senescence… read more here.
Keywords: senescence; crc; cell; related model ... See more keywords
Identification and experimental verification of senescence-related gene signatures and molecular subtypes in idiopathic pulmonary arterial hypertension
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DOI: 10.1038/s41598-024-72979-8
Abstract: Evidences illustrate that cell senescence contributes to the development of pulmonary arterial hypertension. However, the molecular mechanisms remain unclear. Since there may be different senescence subtypes between PAH patients, consistent senescence-related genes (SRGs) were utilized… read more here.
Keywords: senescence; arterial hypertension; pulmonary arterial; molecular subtypes ... See more keywords
A senescence-related signature for predicting the prognosis of breast cancer: A bioinformatics analysis
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DOI: 10.1097/md.0000000000033739
Abstract: Breast cancer is a heterogeneous disease with diverse prognosis and treatment outcomes. Current gene signatures for prognostic prediction are limited to specific subtypes of breast cancer. Cellular senescence is a state of irreversible cell cycle… read more here.
Keywords: senescence related; signature; breast cancer; cancer ... See more keywords
Bioinformatics analysis of the prognostic and clinical value of senescence-related gene signature in papillary thyroid cancer
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DOI: 10.1097/md.0000000000033934
Abstract: Cellular senescence can both inhibit and promote the occurrence of tumors, so how to apply cellular senescence therapy is of great importance. However, it is worth to be analyzed from multiple perspectives by researchers, especially… read more here.
Keywords: senescence; value; senescence related; gene ... See more keywords
Identification of Biomarkers for Acute Myocardial Infarction Based on Cell Senescence Genes and Machine Learning
Sign Up to like & getrecommendations! Published in 2025 at "Anatolian Journal of Cardiology"
DOI: 10.14744/anatoljcardiol.2025.5129
Abstract: Background: This study aims to identify senescence-related biomarkers for ST-elevation myocardial infarction (STEMI) prognosis. Methods: RNA expression data for STEMI samples and controls were obtained from the gene expression omnibus (GEO) database, and cellular senescence… read more here.
Keywords: senescence; cellular senescence; machine learning; myocardial infarction ... See more keywords
Senescence-related signatures predict prognosis and response to immunotherapy in colon cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-24-339
Abstract: Background Colorectal cancer (CRC) is one of the most common cancers. Cellular senescence plays a vital role in carcinogenesis by activating many pathways. In this study, we aimed to identify biomarkers for predicting the survival… read more here.
Keywords: senescence; cancer; cellular senescence; response immunotherapy ... See more keywords
Identification and validation of senescence-related genes in circulating endothelial cells of patients with acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1057985
Abstract: Background Acute myocardial infarction (AMI) is the main clinical cause of death and cardiovascular disease and thus has high rates of morbidity and mortality. The increase in cardiovascular disease with aging is partly the result… read more here.
Keywords: validation; senescence; ami; dataset ... See more keywords
A cellular senescence-related genes model allows for prognosis and treatment stratification of hepatocellular carcinoma: A bioinformatics analysis and experimental verification
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1099148
Abstract: Introduction: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with low 5-year survival rate. Cellular senescence, characterized by permanent and irreversible cell proliferation arrest, plays an important role in tumorigenesis and… read more here.
Keywords: hcc; cellular senescence; model; senescence related ... See more keywords
An Aging and Senescence-Related Gene Signature for Prognosis Prediction in Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.871088
Abstract: Background: Clear cell renal cell carcinoma (ccRCC) is the most common solid lesion in the kidney. This study aims to establish an aging and senescence-related mRNA model for risk assessment and prognosis prediction in ccRCC… read more here.
Keywords: cell; aging senescence; prediction; risk ... See more keywords