Senescence as a therapeutically relevant response to CDK4/6 inhibitors
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DOI: 10.1038/s41388-020-1354-9
Abstract: Cyclin-dependent kinases 4 and 6 (CDK4/6) phosphorylate and inhibit retinoblastoma (RB) family proteins. Hyperphosphorylated RB releases E2F transcription factors, activating a transcriptional program that initiates S phase. Due to the critical role that this pathway… read more here.
Keywords: response; senescence therapeutically; senescence; therapeutically relevant ... See more keywords