Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation
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DOI: 10.1016/j.canlet.2019.12.013
Abstract: Macrophages serve as the first line of communication between tumors and the rest of the immune system, and understanding the interplay between macrophage and tumor cells is essential for developing novel macrophage-based strategy against tumor.… read more here.
Keywords: activation; tumor cells; senescence tumor; tumor ... See more keywords
Abstract SY26-03: Dual targeting of senescence and tumor immunity for cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-sy26-03
Abstract: Senescence induction in cancer works as a potent weapon to eradicate tumorigenesis. Therapies that enhance senescence not only promote a stable cell growth arrest but also work as a strong stimulus for the activation of… read more here.
Keywords: senescence tumor; dual targeting; senescence; cancer ... See more keywords
Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses
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DOI: 10.3390/cancers14061364
Abstract: Simple Summary Despite tremendous treatment efforts, cancer is still one of the leading causes of death, with approximately 10 million deaths in 2020. In the last decade, immunotherapy entered the stage of clinical practice and… read more here.
Keywords: tumor; senescence tumor; cancer; tumor microenvironment ... See more keywords
Senescence of Tumor Cells in Anticancer Therapy—Beneficial and Detrimental Effects
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DOI: 10.3390/ijms231911082
Abstract: Cellular senescence process results in stable cell cycle arrest, which prevents cell proliferation. It can be induced by a variety of stimuli including metabolic stress, DNA damage, telomeres shortening, and oncogenes activation. Senescence is generally… read more here.
Keywords: tumor cells; senescence tumor; senescence; beneficial detrimental ... See more keywords