Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14421-x
Abstract: Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific G-protein… read more here.
Keywords: therapeutic senescence; senescence via; activation; synovial fibroblasts ... See more keywords
DRG2 Accelerates Senescence via Negative Regulation of SIRT1 in Human Diploid Fibroblasts
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/7301373
Abstract: Accumulating evidence suggests that developmentally regulated GTP-binding protein 2 (DRG2), an evolutionarily conserved GTP-binding protein, plays an important role in regulating cell growth, inflammation, and mitochondria dynamics. However, the effect of DRG2 in aging remains… read more here.
Keywords: sirt1; drg2; senescence; senescence via ... See more keywords
PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells
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DOI: 10.3390/biom12081046
Abstract: The appropriate differentiation of endometrial stromal cells (ESCs) into decidual cells is required for embryo implantation and subsequent placentation into humans. Decidualization is accompanied by the appearance of senescent-like cells. We recently reported the secretory… read more here.
Keywords: endometrial stromal; expression; senescence; cellular senescence ... See more keywords