An NIR-Responsive DNA-Mediated Nanotetrahedron Enhances the Clearance of Senescent Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.202000184
Abstract: Senescence is a state of stable cell cycle arrest that can escape apoptosis and lead to aging and numerous age-related diseases. In this study, an upconversion-nanoparticle (UCNP)-centered Au20 -Au30 nanoparticles tetrahedron (UAuTe) is prepared by… read more here.
Keywords: dna; senescent cells; senescent; clearance senescent ... See more keywords
Alarmin Detection in Senescent Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8931-7_8
Abstract: Senescent cells secrete diverse array of proteins. One group of proteins, damage-associated molecular pattern (DAMP) proteins exhibit relocalization from inside to outside the cell. High Mobility Group Box 1 protein (HMGB1) is the founding DAMP… read more here.
Keywords: senescent cells; relocalization; alarmin detection; biology ... See more keywords
Breakdown of green and senescent leaves in Amazonian streams: a case study
Sign Up to like & getrecommendations! Published in 2020 at "Limnology"
DOI: 10.1007/s10201-020-00626-y
Abstract: Allochthonous organic matter in low-order streams is, in general, mainly composed of senescent leaves. However, in tropical streams green leaves can represent an important source of energy. The present study evaluated the decomposition of green… read more here.
Keywords: leaves amazonian; amazonian streams; senescent leaves; green leaves ... See more keywords
Rejuvenation by Therapeutic Elimination of Senescent Cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.014
Abstract: In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing apoptosis. Disrupting this interaction with an all-D amino acid peptide… read more here.
Keywords: cell; senescent cells; therapeutic elimination; rejuvenation therapeutic ... See more keywords
Selective elimination of senescent cells by mitochondrial targeting is regulated via ANT2
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.382
Abstract: Cellular senescence is stable cell cycle arrest limiting proliferative potential of cells. Inability of immune cells to eliminate senescent cells from the organism may lead to development of age-related diseases. We have developed several mitocans,… read more here.
Keywords: mitotam; senescent cells; elimination senescent; selective elimination ... See more keywords
Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2020.111355
Abstract: Senescent cells are deeply involved in the induction of tissue damage and aging-related diseases. The identification of factors that eliminate senescent cells or inhibit the senescence-associated secretory phenotype (SASP) in these cells is necessary. Here,… read more here.
Keywords: secretory phenotype; senescence associated; senescent cells; associated secretory ... See more keywords
Reducing Senescent Cell Burden in Aging and Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2020.03.005
Abstract: Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, and alterations in DNA and chromatin. In preclinical… read more here.
Keywords: medicine; senescent; cell burden; senescent cell ... See more keywords
An Activatable NIR Probe for the Detection and Elimination of Senescent Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00239
Abstract: Cellular senescence is involved in diverse physiological processes. Accumulation of senescent cells can lead to numerous age-related diseases. Therefore, it is of great significance to develop chemical tools to effectively detect and eliminate senescent cells.… read more here.
Keywords: eliminate senescent; gal; detect eliminate; senescent ... See more keywords
Raman and Infrared Spectroscopy Distinguishing Replicative Senescent from Proliferating Primary Human Fibroblast Cells by Detecting Spectral Differences Mainly Due to Biomolecular Alterations.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.6b04264
Abstract: Cellular senescence is a terminal cell cycle arrested state, assumed to be involved in tumor suppression. We studied four human fibroblast cell strains (BJ, MRC-5, IMR-90, and WI-38) from proliferation into senescence. Cells were investigated… read more here.
Keywords: infrared spectroscopy; senescent; senescence; spectroscopy ... See more keywords
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15719-6
Abstract: Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor secretion. Thus, the development of new drugs that cause the… read more here.
Keywords: senescent cells; family protein; provokes senolysis; protein degrader ... See more keywords
Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-29486-z
Abstract: Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with… read more here.
Keywords: senescent; type diabetes; mitochondrially targeted; diabetes mellitus ... See more keywords