DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202401275
Abstract: Compromised osteogenesis and angiogenesis is the character of stem cell senescence, which brought difficulties for bone defects repairing in senescent microenvironment. As the most abundant bone‐related miRNA, miRNA‐21‐5p plays a crucial role in inducing osteogenic… read more here.
Keywords: senescent bone; osteogenesis angiogenesis; osteogenesis; tdn mir ... See more keywords
Compromised osteogenic effect of exosomes internalized by senescent bone marrow stem cells via endocytoses involving clathrin, macropinocytosis and caveolae
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1090914
Abstract: Stem cell senescence leads to progressive functional declines and disrupts the physiological homeostasis of bone environment. Stem cell-derived exosomes are emerging as promising therapeutical approaches to treat diverse aging-related osseous diseases. Herein, a previously reported… read more here.
Keywords: senescent bone; bone; bmscs; macropinocytosis ... See more keywords