Targeting senescence as an anticancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13312
Abstract: Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate… read more here.
Keywords: one two; senescence; senescent cells; anticancer ... See more keywords
An NIR-Responsive DNA-Mediated Nanotetrahedron Enhances the Clearance of Senescent Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.202000184
Abstract: Senescence is a state of stable cell cycle arrest that can escape apoptosis and lead to aging and numerous age-related diseases. In this study, an upconversion-nanoparticle (UCNP)-centered Au20 -Au30 nanoparticles tetrahedron (UAuTe) is prepared by… read more here.
Keywords: dna; senescent cells; senescent; clearance senescent ... See more keywords
Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200364
Abstract: Cellular senescence is a stable cell cycle arrest state that can be triggered by a wide range of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is thought to contribute to… read more here.
Keywords: advances strategies; senescence; detection; senescent cells ... See more keywords
The potential role of senescence in limiting fibrosis caused by aging
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29313
Abstract: Fibrosis‐related diseases carry with them a high mortality rate and their morbidity increases with age. Recent findings indicate that induced senescence in myofibroblasts can limit or reduce myocardial fibrosis, cirrhosis, and idiopathic pulmonary fibrosis, while… read more here.
Keywords: fibrosis; senescence limiting; senescent cells; senescence ... See more keywords
Obesity, Senescence, and Senolytics.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_555
Abstract: Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent… read more here.
Keywords: senescent cells; obesity senescence; senescence; senescence senolytics ... See more keywords
Measurement of Metabolite Changes in Senescent Cells by Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8931-7_13
Abstract: Senescent cells display altered metabolic signatures that can either be causal for aspects the senescent phenotype, or act as biomarkers for senescence. Steady state levels of multiple metabolites change with senescence, and can be detected… read more here.
Keywords: measurement metabolite; mass spectrometry; senescent cells; metabolite changes ... See more keywords
Alarmin Detection in Senescent Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8931-7_8
Abstract: Senescent cells secrete diverse array of proteins. One group of proteins, damage-associated molecular pattern (DAMP) proteins exhibit relocalization from inside to outside the cell. High Mobility Group Box 1 protein (HMGB1) is the founding DAMP… read more here.
Keywords: senescent cells; relocalization; alarmin detection; biology ... See more keywords
A novel Sudan Black B-based analogue revives lipofuscin as a biomarker for in vivo senescence
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2452-8
Abstract: Senescence is a fundamental cellular mechanism that has received increasing attention in recent years as a potentially important contributor to developmental, physiological and pathological processes including aging [1]. The term was initially proposed by Hayflick… read more here.
Keywords: senescent cells; senescence; cell cycle; stress ... See more keywords
Caveolin-1, a master regulator of cellular senescence
Sign Up to like & getrecommendations! Published in 2020 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-020-09875-w
Abstract: Cellular senescence is a feature of most somatic cells. It is characterized by an irreversible cell cycle arrest and by the ability to secrete a plethora of mediators of inflammation and growth factors, which can… read more here.
Keywords: senescent cells; senescence; cellular senescence; cancer ... See more keywords
The role of cellular senescence in aging through the prism of Koch-like criteria
Sign Up to like & getrecommendations! Published in 2018 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2017.10.004
Abstract: Since Hayflick's discovery of cellular senescence (CS), a great volume of knowledge in the field has been accumulated and intensively discussed. Here, we attempted to organize the evidence "for" and "against" the hypothesized causal role… read more here.
Keywords: age related; senescent cells; koch like; role ... See more keywords
Senescent cells as promising targets to tackle age-related diseases
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101251
Abstract: As the world's population progressively ages, the burden on the socio-economic and health systems is escalating, demanding sustainable and lasting solutions. Cellular senescence, one of the hallmarks of ageing, is a state of irreversible cell… read more here.
Keywords: age related; senescent cells; related diseases; senescence ... See more keywords