Targeting senescence as an anticancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13312
Abstract: Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate… read more here.
Keywords: one two; senescence; senescent cells; anticancer ... See more keywords
An NIR-Responsive DNA-Mediated Nanotetrahedron Enhances the Clearance of Senescent Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.202000184
Abstract: Senescence is a state of stable cell cycle arrest that can escape apoptosis and lead to aging and numerous age-related diseases. In this study, an upconversion-nanoparticle (UCNP)-centered Au20 -Au30 nanoparticles tetrahedron (UAuTe) is prepared by… read more here.
Keywords: dna; senescent cells; senescent; clearance senescent ... See more keywords
Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200364
Abstract: Cellular senescence is a stable cell cycle arrest state that can be triggered by a wide range of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is thought to contribute to… read more here.
Keywords: advances strategies; senescence; detection; senescent cells ... See more keywords
The potential role of senescence in limiting fibrosis caused by aging
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29313
Abstract: Fibrosis‐related diseases carry with them a high mortality rate and their morbidity increases with age. Recent findings indicate that induced senescence in myofibroblasts can limit or reduce myocardial fibrosis, cirrhosis, and idiopathic pulmonary fibrosis, while… read more here.
Keywords: fibrosis; senescence limiting; senescent cells; senescence ... See more keywords
NK‐Cell‐Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy‐Induced Senescent Osteosarcoma Cells
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70123
Abstract: ABSTRACT Osteosarcoma (OS) is a type of bone tumour characterized by high risk of metastatic progression and recurrence after therapy. Traditional tumour treatment methods such as radiotherapy and chemotherapy can lead to the accumulation of… read more here.
Keywords: extracellular vesicles; senescent cells; chemotherapy; derived extracellular ... See more keywords
Fisetin Clears Senescent Cells Through the Pi3k‐Akt‐Bcl‐2/Bcl‐xl Pathway to Alleviate Diabetic Aortic Aging
Sign Up to like & getrecommendations! Published in 2025 at "Phytotherapy Research"
DOI: 10.1002/ptr.8507
Abstract: Vascular aging is a major contributor to age‐related cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) induced early arterial aging and excessive senescent cells (SCs) burden in vessels. Inhibiting cellular senescence or eliminating SCs… read more here.
Keywords: senescent cells; bcl bcl; aortic aging; fisetin ... See more keywords
Obesity, Senescence, and Senolytics.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_555
Abstract: Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent… read more here.
Keywords: senescent cells; obesity senescence; senescence; senescence senolytics ... See more keywords
Measurement of Metabolite Changes in Senescent Cells by Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8931-7_13
Abstract: Senescent cells display altered metabolic signatures that can either be causal for aspects the senescent phenotype, or act as biomarkers for senescence. Steady state levels of multiple metabolites change with senescence, and can be detected… read more here.
Keywords: measurement metabolite; mass spectrometry; senescent cells; metabolite changes ... See more keywords
Alarmin Detection in Senescent Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8931-7_8
Abstract: Senescent cells secrete diverse array of proteins. One group of proteins, damage-associated molecular pattern (DAMP) proteins exhibit relocalization from inside to outside the cell. High Mobility Group Box 1 protein (HMGB1) is the founding DAMP… read more here.
Keywords: senescent cells; relocalization; alarmin detection; biology ... See more keywords
A novel Sudan Black B-based analogue revives lipofuscin as a biomarker for in vivo senescence
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2452-8
Abstract: Senescence is a fundamental cellular mechanism that has received increasing attention in recent years as a potentially important contributor to developmental, physiological and pathological processes including aging [1]. The term was initially proposed by Hayflick… read more here.
Keywords: senescent cells; senescence; cell cycle; stress ... See more keywords
Transcriptional activation of genes associated with the matrisome is a common feature of senescent endothelial cells
Sign Up to like & getrecommendations! Published in 2025 at "Biogerontology"
DOI: 10.1007/s10522-025-10191-5
Abstract: Cellular senescence is a stable cell cycle arrest that occurs in response to various stress stimuli and affects multiple cell types, including endothelial cells (ECs). Senescent cells accumulate with age, and their removal has been… read more here.
Keywords: senescence; senescent endothelial; senescent cells; genes associated ... See more keywords