Navitoclax (ABT-263) rejuvenates human skin by eliminating senescent dermal fibroblasts in a mouse/human chimeric model.
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DOI: 10.1089/rej.2022.0048
Abstract: Chronic senescence, such as aging, contributes to age-related tissue dysfunction and disease development. The accumulation of senescent fibroblasts and the senescence-associated secretory phenotype are particularly implicated in this process. Removal of senescent cells has been… read more here.
Keywords: dermal fibroblasts; abt 263; skin; human skin ... See more keywords