Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94097-5
Abstract: Senescent vascular cells are detected in atherosclerotic lesion, and its involvement in the development of atherosclerosis has been revealed; however, whether and the mechanism by which endothelial cell (EC) senescence is causally implicated in atherosclerosis… read more here.
Keywords: epigenetic alteration; alteration consequently; senescent ecs; senescence ... See more keywords
Abstract 4366240: Transient pharmacological reprogramming reverses endothelial senescence and promotes vascular regeneration
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4366240
Abstract: Endothelial cell (EC) senescence has been identified as a significant contributor to the development of cardiovascular disease, resulting in impaired angiogenesis and tissue regeneration. Consequently, the reversal of EC senescence emerges as a promising therapeutic… read more here.
Keywords: senescence; reprogramming; senescent ecs; transient pharmacological ... See more keywords
Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cognitive Impairment.
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DOI: 10.1212/wnl.0000000000210063
Abstract: Age is an important risk factor of stroke, cognitive decline, and dementia. Senescent endothelial cells (ECs) accumulate with advancing age through exposure to cellular stress, such as that exerted by hypertension and diabetes. These senescent… read more here.
Keywords: cognitive impairment; senescent ecs; stroke cognitive; barrier ... See more keywords