Comparison of the effects of fractional microneedle radiofrequency and microneedling on modulating the senescent fibroblast milieu in aged skin
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DOI: 10.1038/s41598-025-02545-3
Abstract: Skin ageing is a complex and multifaceted biological process that involves the accumulation of senescent dermal fibroblasts. While fractional microneedle radiofrequency (MNRF) is widely used for skin rejuvenation, the underlying molecular mechanisms are unknown. This… read more here.
Keywords: senescent fibroblasts; fractional microneedle; fibroblast milieu; milieu aged ... See more keywords
Role of senescent fibroblasts in the development of idiopathic guttate hypomelanosis
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DOI: 10.1111/bjd.18801
Abstract: BACKGROUND Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentary disorder occurring mainly on exposed areas in elderly individuals. Long-term sun exposure is thought to be a main cause of IGH but the pathogenesis is still… read more here.
Keywords: guttate hypomelanosis; senescent; idiopathic guttate; senescent fibroblasts ... See more keywords
Abstract 2518: Heterogeneity of cytokine secretion in single senescent fibroblasts is impacted by ONC201 and ABT-263
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DOI: 10.1158/1538-7445.am2023-2518
Abstract: Cellular senescence and the associated secretory phenotype (SASP) promote cancer. During the process of aging, cellular and molecular changes that occur in non-cancerous cells can alter responses to cancer therapy and immune response in the… read more here.
Keywords: abt 263; senescent; senescent fibroblasts; cancer ... See more keywords
Abstract 301: PARP inhibitor-induced senescent fibroblasts enhance prostate cancer cell proliferation and suppress NK cell-mediated cytotoxicity
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DOI: 10.1158/1538-7445.am2025-301
Abstract: Prostate cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men. Despite initial tumor response to androgen deprivation therapy (ADT), most patients with PCa progress to a castrate-resistant disease state. Therapy-induced cellular… read more here.
Keywords: cancer; pca; senescent fibroblasts; cell ... See more keywords
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis
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DOI: 10.3389/fcell.2020.593283
Abstract: Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular senescence means a non-proliferative but viable cellular physiological state. It is the basis of aging, and it exists in the… read more here.
Keywords: idiopathic pulmonary; senescence; pulmonary fibrosis; ipf ... See more keywords
GALC Triggers Tumorigenicity of Colorectal Cancer via Senescent Fibroblasts
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DOI: 10.3389/fonc.2020.00380
Abstract: Colorectal cancer (CRC)-associated senescent fibroblasts may play a crucial role in tumor progression, but the mechanism remains unclear. In order to solve this complicated problem, we randomly collected 16 patients with CRC, who had been… read more here.
Keywords: colorectal cancer; expression; crc; cell ... See more keywords
Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma.
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DOI: 10.3892/or.2025.9031
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrous stroma, within which a subset of fibroblasts function as cancer-associated fibroblasts (CAFs) and contribute to tumor progression. Some of these fibroblasts undergo senescence and promote… read more here.
Keywords: senescence; factor expression; senescent fibroblasts; tumor ... See more keywords