Senescent Hepatocytes in Decompensated Liver Show Reduced UPRMT and Its Key Player, CLPP, Attenuates Senescence In Vitro
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.03.001
Abstract: Background and Aims Non-dividing hepatocytes in end-stage liver disease indicates permanent growth arrest similar to senescence. Identifying senescence in vivo is often challenging and mechanisms inhibiting senescence are poorly understood. In lower organisms mitochondrial unfolded… read more here.
Keywords: senescent hepatocytes; hepatocyte senescence; cirrhosis; senescence ... See more keywords
A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes
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DOI: 10.1158/0008-5472.can-22-1477
Abstract: Liver damage induces a compensatory regenerative response that can drive premalignant to malignant transformation of senescent hepatocytes. read more here.
Keywords: senescent hepatocytes; malignant transformation; transformation senescent; premalignant malignant ... See more keywords