Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29824-1
Abstract: Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic dissemination. Removal of senescent… read more here.
Keywords: tumor cells; cancer; senolytic therapy; tumor ... See more keywords
Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24961
Abstract: Therapy-induced senescence is a major cellular response to chemotherapy in solid tumors. Senescent tumor cells acquire a secretory phenotype, or SASP, and produce pro-inflammatory factors, whose expression is largely under NF-κB transcriptional control. Secreted factors… read more here.
Keywords: secretory phenotype; senescent tumor; tumor cells; senescence ... See more keywords
Detection of Cellular Senescence Reveals the Existence of Senescent Tumor Cells within Invasive Breast Carcinomas and Related Metastases
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061860
Abstract: Simple Summary Oncogene-induced senescence constitutes a barrier to carcinogenesis by arresting cells at risk of malignant transformation. However, numerous findings suggest that senescent cells conversely promote tumor growth and metastatic progression, for example, through the… read more here.
Keywords: tumor cells; breast carcinomas; senescence; tumor ... See more keywords