Ultrathin ZIF‐8 Coating‐Reinforced Enzyme Nanoformulation Avoids Lysosomal Degradation for Senile Osteoporosis Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202410931
Abstract: Antioxidant enzymes are considered to be the most direct and safe candidates to effectively resist oxidative stress and treat senile osteoporosis. However, due to their size, existing enzyme delivery carriers are inevitably endocytosed by cells… read more here.
Keywords: senile osteoporosis; zif coating; ultrathin zif; osteoporosis ... See more keywords
Efficacy, Mechanism, and Structure-Activity Relationship of 6-Methoxy Benzofuran Derivatives as a Useful Tool for Senile Osteoporosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01377
Abstract: Most patients with senile osteoporosis (SOP) are severely deficient in bone mass, and treatments using bone resorption inhibitors, such as bisphosphonates, have shown limited efficacy. Small-molecule osteogenesis-promoting drugs are required to improve the treatment for… read more here.
Keywords: structure activity; senile osteoporosis; osteoporosis; efficacy ... See more keywords
GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-025-01543-2
Abstract: The abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is an important cause of senile osteoporosis (SOP). Glutamine synthetase (GLUL) is a key enzyme in glutamine biosynthesis; however, its functional role in SOP… read more here.
Keywords: differentiation; senile osteoporosis; glcnacylation; osteogenic differentiation ... See more keywords
FKBP5 Induces Senescence in BMSCs and Inhibits Osteogenic Differentiation Through the Canonical WNT/β‐Catenin Signalling Pathway in Senile Osteoporosis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70552
Abstract: Senile osteoporosis and its associated fractures significantly contribute to increased morbidity, mortality, and healthcare costs among older adults. Further research is needed to elucidate the molecular mechanisms underlying senile osteoporosis. This study found that FKBP5… read more here.
Keywords: fkbp5; canonical wnt; senile osteoporosis; osteogenic differentiation ... See more keywords
Effect of Lymphocyte Subsets on Bone Density in Senile Osteoporosis: A Retrospective Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/3337622
Abstract: Background Several studies have shown that lymphocyte subsets can mediate the occurrence of osteoporosis (OP); however, the predictive ability of lymphocyte subsets in senile OP has not been elucidated. Purpose To investigate the ability of… read more here.
Keywords: density; senile osteoporosis; lymphocyte subsets; osteoporosis ... See more keywords
Clinical effect of Zoledronic Acid in the treatment of Senile Osteoporosis
Sign Up to like & getrecommendations! Published in 2020 at "Pakistan Journal of Medical Sciences"
DOI: 10.12669/pjms.36.7.1964
Abstract: Objective: To investigate the clinical efficacy of zoledronic acid in the treatment of senile osteoporosis. Methods: One hundred and six cases of senile osteoporosis who visited to our hospital from August 2017 to December 2018… read more here.
Keywords: control group; senile osteoporosis; treatment; group ... See more keywords
Senile osteoporosis is associated with disc degeneration.
Sign Up to like & getrecommendations! Published in 2018 at "Quantitative imaging in medicine and surgery"
DOI: 10.21037/qims.2018.07.04
Abstract: Osteoporosis and disc degeneration of the spine are common conditions that primarily affect the elderly with significant impact on the quality of life. A number of studies reported that higher lumbar spine bone mineral density… read more here.
Keywords: associated disc; senile osteoporosis; degeneration; disc degeneration ... See more keywords
Gut Microbiota Feature of Senile Osteoporosis by Shallow Shotgun Sequencing Using Aged Rats Model
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13040619
Abstract: Senile osteoporosis is defined as an age-related bone metabolic disorder, which is characterized by bone loss and decreased bone fragility. Gut microbiota (GM) could regulate the bone metabolic process and be closely related to senile… read more here.
Keywords: senile osteoporosis; two groups; shallow shotgun; osteoporosis ... See more keywords