Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.03.008
Abstract: Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins… read more here.
Keywords: senolysis; oxylipin biosynthesis; prostaglandin; senescence ... See more keywords
Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis
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DOI: 10.3390/ijms232214251
Abstract: Within the present study we proposed a novel approach for senolysis based on the simultaneous disturbance of the several homeostasis-maintaining systems in senescent cells including intracellular ionic balance, energy production and intracellular utilization of damaged… read more here.
Keywords: maintaining systems; ionophore nigericin; homeostasis maintaining; senolysis ... See more keywords