Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.
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DOI: 10.1038/s41467-022-29824-1
Abstract: Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic dissemination. Removal of senescent… read more here.
Keywords: tumor cells; cancer; senolytic therapy; tumor ... See more keywords