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   Articles with "senp1" as a keyword



Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1‐mediated deSUMOylation of SIRT3

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13539

Abstract: Bone marrow mesenchymal stem cells (BMSCs) are capable of multidirectional differentiation, and engrafted BMSCs can be used to replace damaged chondrocytes for treatment of intervertebral disc disease. However, chondroblast differentiation of implanted BMSCs is inhibited… read more here.

Keywords: sirt3; leptin; senp1; bmscs ... See more keywords

SENP1‐Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202400741

Abstract: Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, the authors show that sentrin‐specific protease 1 (SENP1) is downregulated in post‐MI mice and in patients with severe heart… read more here.

Keywords: fibrosis; hsp90ab1 desumoylation; senp1 mediated; mediated hsp90ab1 ... See more keywords

SENP1/HIF‐1α axis works in angiogenesis of human dental pulp stem cells

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recommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.22436

Abstract: Dental diseases seriously affect the quality of life. Studying the mechanism of dental pulp stem cells (DPSCs) had far‐reaching significance for the therapy of dental diseases. In this paper, we studied the small ubiquitin‐like modifier‐specific… read more here.

Keywords: stem cells; hif; senp1; dental pulp ... See more keywords
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SENP1 participates in Irinotecan resistance in human colon cancer cells

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recommendations! Published in 2021 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.29946

Abstract: Colorectal cancer is one of the most prevalent cancers in the world. Chemoresistance has always been a problem encountered in its treatment. It is known that SUMOylation may regulate protein stability and decomposition, and even… read more here.

Keywords: senp1; cpt; colorectal cancer; human colon ... See more keywords

SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis

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recommendations! Published in 2025 at "Oncogene"

DOI: 10.1038/s41388-025-03302-6

Abstract: Aberrant SUMOylation is associated with the progression of colorectal cancer (CRC). The SUMO-specific protease 1 (SENP1)-induced deSUMOylation of different target substrates plays specific roles in CRC. In this study, we dissected the SENP1-interacting protein complex… read more here.

Keywords: senp1 mediated; senp1 ybx1; desumoylation; protein ... See more keywords

Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis.

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recommendations! Published in 2021 at "Bioengineered"

DOI: 10.1080/21655979.2021.1967076

Abstract: Increasing evidence has indicated the implications of circular RNAs (circRNAs) in the development of colorectal cancer (CRC). In this study, we investigated the functional role and mechanism of circ_0089153 in CRC pathogenesis. The expression levels… read more here.

Keywords: mir 198; senp1; rna; formation ... See more keywords

SENP1 exacerbates acute myeloid leukemia by enhancing BECN1-dependent autophagy through PTBP1 deSUMOylation.

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recommendations! Published in 2024 at "Journal of leukocyte biology"

DOI: 10.1093/jleuko/qiae143

Abstract: Genetic association between SUMO-specific protease 1 (SENP1) and acute myeloid leukemia (AML) has been validated. However, the mechanism by which SENP1 affects AML proliferation, apoptosis, and autophagy remains unknown. The levels of SENP1 and polypyrimidine… read more here.

Keywords: acute myeloid; aml; ptbp1; autophagy ... See more keywords

TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.789348

Abstract: Small ubiquitin-like modifier (SUMO) modification plays an important regulatory role in T cell receptor (TCR) signaling transduction. SUMO-specific proteases (SENPs) have dual-enzyme activities; they can both process SUMO precursors as endopeptidases and participate in SUMO… read more here.

Keywords: senp1; tcr induced; activity; phosphorylation ... See more keywords

SENP1 Aberrance and Its Linkage to Clinical Features, Adjuvant Regimen, and Prognosis in Patients With Surgical Non-small Cell Lung Cancer Receiving Adjuvant Chemotherapy

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recommendations! Published in 2022 at "Frontiers in Surgery"

DOI: 10.3389/fsurg.2021.771785

Abstract: Background Small ubiquitin-like modifier-specific protease 1 (SENP1) plays vital roles in cancer progression and chemoresistance, but its prognostic value in non-small cell lung cancer (NSCLC) is vague. This study aimed to explore the correlation of… read more here.

Keywords: senp1; adjuvant chemotherapy; receiving adjuvant; patients surgical ... See more keywords

Insights into the Allosteric Effect of SENP1 Q597A Mutation on the Hydrolytic Reaction of SUMO1 via an Integrated Computational Study

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27134149

Abstract: Small ubiquitin-related modifier (SUMO)-specific protease 1 (SENP1) is a cysteine protease that catalyzes the cleavage of the C-terminus of SUMO1 for the processing of SUMO precursors and deSUMOylation of target proteins. SENP1 is considered to… read more here.

Keywords: hydrolytic reaction; reaction sumo1; senp1; q597a mutation ... See more keywords

SENP1 promotes triple-negative breast cancer invasion and metastasis via enhancing CSN5 transcription mediated by GATA1 deSUMOylation

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recommendations! Published in 2022 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.60594

Abstract: TNBC is characterized by high incidence of visceral metastasis and lacks effective clinical targets. This study aims to delineate the molecular mechanisms of SENP1 in TNBC invasion and metastasis. By using IHC to test the… read more here.

Keywords: expression; tnbc; metastasis; senp1 ... See more keywords