Hepatic SENP2 Controls Systemic Metabolism via SUMOylation-dependent Regulation of Liver-Adipose Tissue Crosstalk.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31881
Abstract: BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD), characterized by aberrant triglycerides accumulation in liver, affects the metabolism remodeling of hepatic and non-hepatic tissues by secreting altered hepatokines. SUMO-specific protease 2 (SENP2) is responsible for… read more here.
Keywords: sumoylation; metabolism; liver adipose; senp2 ... See more keywords
SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110408
Abstract: The adipose tissue is a key site regulating energy metabolism. One of the contributing factors behind this is browning of white adipose tissue (WAT). However, knowledge of the intracellular determinants of the browning process remains… read more here.
Keywords: ebp senp2; senp2 suppresses; browning white; senp2 ... See more keywords
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical science"
DOI: 10.1042/cs20201408
Abstract: Posttranslational modification by SUMO is a key regulator of cell proliferation and can be readily reversed by a family of SUMO-specific proteases (SENPs), making SUMOylation an ideal regulatory mechanism for developing novel therapeutic strategies for… read more here.
Keywords: cardiac regeneration; sumoylation; senp2; proliferation ... See more keywords
Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjx055
Abstract: One major function of adipocytes is to store excess energy in the form of triglycerides. Insufficient adipose lipid storage is associated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. In this… read more here.
Keywords: sumoylation; setdb1; adipose lipid; senp2 ... See more keywords
Identification of Natural Products as SENP2 Inhibitors for Targeted Therapy in Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.817990
Abstract: Aims: Sentrin-specific protease -2 (SENP2) is involved in deSUMOylation. Increased deSUMOylation in murine hearts by SENP2 upregulation resulted in cardiac dysfunction and congenital heart defects. Natural compounds via regulating cell proliferation and survival, induce cell… read more here.
Keywords: identification natural; heart failure; senp2; natural products ... See more keywords