Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2046898
Abstract: ABSTRACT The selective clearance of mitochondria by mitophagy is an important quality control mechanism for maintaining mitochondrial and cellular health. Iron chelation, for example by the compound deferiprone (DFP), leads to a specific form of… read more here.
Keywords: senp3; fis1; dfp; iron chelation ... See more keywords
Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury
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DOI: 10.1371/journal.pone.0213331
Abstract: Interruption of blood supply to the heart is a leading cause of death and disability. However, the molecular events that occur during heart ischemia, and how these changes prime consequent cell death upon reperfusion, are… read more here.
Keywords: heart; reperfusion; ischemia; ischemia reperfusion ... See more keywords
SENP3 promotes tumor progression and is a novel prognostic biomarker in triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.972969
Abstract: Background The clinical outcome of triple-negative breast cancer (TNBC) is poor. Finding more targets for the treatment of TNBC is an urgent need. SENPs are SUMO-specific proteins that play an important role in SUMO modification.… read more here.
Keywords: prognosis; triple negative; senp3; risk ... See more keywords