Identification of AI-2 Quorum Sensing Inhibitors in Vibrio harveyi Through Structure-Based Virtual Screening.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7309-5_26
Abstract: Quorum sensing (QS) is a cell-to-cell communication system that regulates gene expression as a result of the production and perception of signal molecules called autoinducers (AIs). AI-2 is a QS autoinducer produced by both Gram-negative… read more here.
Keywords: virtual screening; vibrio harveyi; quorum sensing; harveyi ... See more keywords
Quorum sensing inhibitors: can endophytes be prospective sources?
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DOI: 10.1007/s00203-017-1437-3
Abstract: Endophytes are microbes which reside inside the plant tissues asymptomatically or causing pathogenicity to the host plant for a brief period. Owing to their presence in a specialized niche, endophytes are capable of synthesizing diverse… read more here.
Keywords: prospective sources; endophytes prospective; quorum sensing; endophytic microbes ... See more keywords
Screening Strategies for Quorum Sensing Inhibitors in Combating Bacterial Infection
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DOI: 10.1016/j.jpha.2021.03.009
Abstract: Abstract Interference with quorum sensing (QS) represents an antivirulence strategy with significant promise for the treatment of bacterial infections and a new approach for restoring antibiotic tolerance. Over the past two decades, a novel series… read more here.
Keywords: sensing inhibitors; bacterial infection; screening strategies; quorum sensing ... See more keywords
Long-Chain 4-Aminoquinolines as Quorum Sensing Inhibitors in Serratia marcescens and Pseudomonas aeruginosa.
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DOI: 10.1021/acschembio.6b01149
Abstract: Antibiotic resistance has become a serious global threat to public health; therefore, improved strategies and structurally novel antimicrobials are urgently needed to combat infectious diseases. Here we report a new type of highly potent 4-aminoquinoline… read more here.
Keywords: pseudomonas aeruginosa; inhibitors serratia; quorum sensing; serratia marcescens ... See more keywords
Design, synthesis and evaluation of oxazolopyridinone derivatives as quorum sensing inhibitors.
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DOI: 10.2139/ssrn.4178008
Abstract: The antibiotic crisis is associated with the appearance of multidrug resistant (MDR) pathogens, which has caused severe bacterial infections and imposed a huge burden on modern society. Therefore, there is an urgent need to develop… read more here.
Keywords: design synthesis; oxazolopyridinone derivatives; sensing inhibitors; quorum sensing ... See more keywords
Virtual Screening and Biomolecular Interactions of CviR-Based Quorum Sensing Inhibitors Against Chromobacterium violaceum
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2018.00292
Abstract: The rise of bacterial multi drug resistance becomes a global threat to the mankind. Therefore it is essential to find out alternate strategies to fight against these “super bugs.” Quorum sensing (QS) is a cell-to-cell… read more here.
Keywords: virtual screening; qsis; quorum sensing; chromobacterium violaceum ... See more keywords
The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors
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DOI: 10.3390/md20080488
Abstract: The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic activity is one of the important inducements for bacteria to develop drug resistance. Bacteria gain drug resistance through spontaneous mutation so as to achieve the… read more here.
Keywords: system; sensing inhibitors; architecture pseudomonas; quorum sensing ... See more keywords
Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2018 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.14.260
Abstract: Interfering with bacterial cell-to-cell communication is a promising strategy to combat antimicrobial resistance. The natural product hamamelitannin and several of its analogues have been identified as quorum sensing inhibitors. In this paper the synthesis of… read more here.
Keywords: synthesis pyrrolidine; pyrrolidine based; hamamelitannin; quorum sensing ... See more keywords