TGF‐β1 enhances the activity of acid‐sensing ion channel in rat primary sensory neurons
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24481
Abstract: Transforming growth factor‐β1 (TGF‐β1) is an important member of multifunctional growth factor superfamily. It has been implicated in pain signaling, but little is known about the underlying mechanisms. Herein, we report that TGF‐β1 can exert… read more here.
Keywords: sensing ion; tgf; activity acid; activity ... See more keywords
Resveratrol inhibits the activity of acid‐sensing ion channels in male rat dorsal root ganglion neurons
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25060
Abstract: Resveratrol can relieve pain under various pain conditions. One of the mechanisms of resveratrol analgesia is the regulation of ion channels. Acid‐sensing ion channels (ASICs) are expressed predominantly in nociceptive sensory neurons to detect changes… read more here.
Keywords: acid sensing; resveratrol; male rat; sensing ion ... See more keywords
Glutamate potentiates heterologously expressed homomeric acid-sensing ion channel 1a.
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22227
Abstract: Acid-sensing ion channels (ASICs) participate in synaptic transmission due to acidic content of synaptic vesicles, but their contribution in the postsynaptic currents is small. This stimulates attempts to find endogenous ASIC potentiators that could enhance… read more here.
Keywords: sensing ion; glutamate potentiates; acid sensing;
Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.09.001
Abstract: Despite the sequence homology between acid-sensing ion channels (ASICs) and epithelial sodium channel (ENaCs), these channel families display very different functional characteristics. Whereas ASICs are gated by protons and show a relatively low degree of… read more here.
Keywords: sensing ion; ion channels; ion; pore ... See more keywords
Acid sensing ion channels in rat cerebral arteries: Probing the expression pattern and vasomotor activity.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.04.054
Abstract: AIMS The recent identification of acid sensing ion channels (ASICs) in vascular beds suggests their possible involvement in modulating vasomotor tone. Therefore, we investigated the gene expression profiles of ASIC subtypes in the middle cerebral… read more here.
Keywords: sensing ion; ion channels; vasomotor; expression ... See more keywords
Acid-Sensing Ion Channel 1a Modulates NMDA Receptor Function Through Targeting NR1/NR2A/NR2B Triheteromeric Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.03.044
Abstract: The over-activation of N-methyl-D-aspartate receptors (NMDARs) is the main cause of neuronal death in brain ischemia. Both the NMDAR and the Acid-sensing ion channel 1a (ASIC1a) are present in the postsynaptic membrane of the central… read more here.
Keywords: sensing ion; nr1 nr2a; asic1a; ion channel ... See more keywords
Acid‐sensing ion channel 1a is required for mGlu receptor dependent long‐term depression in the hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.01.028
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Acid‐sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are widely distributed in the mammalian nervous system. ASIC1a is highly permeable to Ca2+ and are thought… read more here.
Keywords: sensing ion; mglu receptor; receptor; group mglu ... See more keywords
Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-37426-5
Abstract: Modulation by neuropeptides enhances several functions of acid-sensing ion channels (ASICs), such as pain sensation and acid-induced neuronal injury. The acid-induced opening of ASICs is transient, because of a rapid desensitization. Neuropeptides containing an Arg-Phe-amide… read more here.
Keywords: central vestibule; modulation; sensing ion; domain ... See more keywords
Acid-sensing ion channel 3: An analgesic target
Sign Up to like & getrecommendations! Published in 2020 at "Channels"
DOI: 10.1080/19336950.2020.1852831
Abstract: ABSTRACT Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation… read more here.
Keywords: sensing ion; asic3; ion channel; channel ... See more keywords
Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220243
Abstract: The extracellular Ca2+ concentration changes locally under certain physiological and pathological conditions. Such variations affect the function of ion channels of the nervous system and consequently also neuronal signalling. We investigated here the mechanisms by… read more here.
Keywords: acid sensing; ion channel; channel pore; ion ... See more keywords
Anti-allodynic effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic migrainein rodents
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14462
Abstract: Background and purpose: Acid-sensing ion channels (ASICs) are neuronal proton sensors emerging as potential therapeutic targets in pain of the orofacial region. Amiloride, a non‐specific ASIC blocker, has been shown to exert beneficial effects in… read more here.
Keywords: sensing ion; effects systemic; ion channels; acute chronic ... See more keywords