Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR).
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_41
Abstract: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that plays a key role in calcium homeostasis, by sensing free calcium levels in blood and regulating parathyroid hormone secretion in response. The CaSR is highly… read more here.
Keywords: receptor casr; casr; calcium; sensing receptor ... See more keywords
NPS 2143, a selective calcium-sensing receptor antagonist inhibits lipopolysaccharide-induced pulmonary inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular immunology"
DOI: 10.1016/j.molimm.2017.07.012
Abstract: NPS 2143, a novel and selective antagonist of calcium-sensing receptor (CaSR) has been reported to possess anti-inflammatory activity. In the present study, we examined the protective effect of NPS 2143 on lipopolysaccharide (LPS)-induced acute lung… read more here.
Keywords: nps; nps 2143; antagonist; sensing receptor ... See more keywords
Proton-sensing receptor GPR132 facilitates migration of astrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Research"
DOI: 10.1016/j.neures.2020.10.001
Abstract: Astrocytes are one of the first responders to central nervous system (CNS) injuries such as spinal cord injury (SCI). They are thought to repress injury-induced CNS inflammation as well as inhibit axonal regeneration. While reactive… read more here.
Keywords: receptor gpr132; lesion site; migration; proton sensing ... See more keywords
Dietary γ-glutamyl valine (γ-EV) ameliorates TNF-α induced vascular inflammation via endothelial calcium-sensing receptor (CaSR).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c04526
Abstract: γ-glutamyl valine (γ-EV), commonly found in edible beans, was shown to reduce gastrointestinal inflammation via activation of calcium-sensing receptor (CaSR). The present study aimed to evaluate the efficacy of γ-EV in modulating the TNF-α induced… read more here.
Keywords: receptor casr; inflammation via; casr; sensing receptor ... See more keywords
Implications of the calcium-sensing receptor in ischemia/reperfusion
Sign Up to like & getrecommendations! Published in 2017 at "Acta Cardiologica"
DOI: 10.1080/00015385.2017.1291136
Abstract: Abstract The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) which was first isolated from bovine parathyroid glands. Its complex structure has been well characterized, which helped to better understand its function. The CaSR… read more here.
Keywords: reperfusion; casr; implications calcium; receptor ... See more keywords
Calcium-sensing Receptor is not Expressed in the Absorptive Enterocytes of Weaned Piglets.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal science"
DOI: 10.1093/jas/skac085
Abstract: The calcium-sensing receptor (CaSR) is a kokumi receptor that plays an essential role in nutrient sensing and animal physiology, growth, and development. Pig CaSR (pCaSR) was identified and characterized in the intestine. However, further research… read more here.
Keywords: calcium sensing; receptor expressed; expressed absorptive; weaned piglets ... See more keywords
Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?
Sign Up to like & getrecommendations! Published in 2022 at "European Respiratory Journal"
DOI: 10.1183/13993003.02103-2021
Abstract: In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy… read more here.
Keywords: calcium sensing; therapy; allosteric modulators; sensing receptor ... See more keywords
Functional Assessment of Calcium-Sensing Receptor Variants Confirms Familial Hypocalciuric Hypercalcemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvac025
Abstract: Abstract Context In the clinic it is important to differentiate primary hyperparathyroidism (PHPT) from the more benign, inherited disorder, familial hypocalciuric hypercalcemia (FHH). Since the conditions may sometimes overlap biochemically, identification of calcium-sensing receptor (CASR)… read more here.
Keywords: hypocalciuric hypercalcemia; functional assessment; sensing receptor; calcium sensing ... See more keywords
Cinacalcet therapy in an infant with an R185Q calcium-sensing receptor mutation causing hyperparathyroidism: a case report and review of the literature
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DOI: 10.1515/jpem-2018-0307
Abstract: Abstract Background Neonatal severe hyperparathyroidism (NSHPT) is commonly treated with either parathyroidectomy or pharmacologic agents with varying efficacy and numerous side effects. Reports of using cinacalcet for NSHPT have increased, however, the effective dose for… read more here.
Keywords: cinacalcet therapy; hyperparathyroidism; case; calcium ... See more keywords
Successful use of cinacalcet monotherapy in the management of siblings with homozygous calcium-sensing receptor mutation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2021-0632
Abstract: Abstract Objectives Neonatal severe hyperparathyroidism (NSHPT) due to pathogenic mutations in the calcium-sensing receptor (CASR) is a serious medical condition that can lead to symptomatic hypercalcaemia and has detrimental effects on a child’s growth and… read more here.
Keywords: cinacalcet; calcium sensing; cinacalcet monotherapy; sensing receptor ... See more keywords
Calcium-Sensing Receptor Arbitrates Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells via the G Protein-PLC-IP3 Pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2019025189
Abstract: Pulmonary arterial hypertension (PAH), also known as broilers ascites syndrome, is characterized by hypoxia, pulmonary artery pressure, and right heart failure. However, less information is available about the molecular mechanisms of PAH. We evaluated the… read more here.
Keywords: pulmonary artery; artery smooth; artery; calcium sensing ... See more keywords