Mitochondrial acute oxygen sensing and signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in biochemistry and molecular biology"
DOI: 10.1080/10409238.2021.2004575
Abstract: Oxygen (O2) is essential for life and therefore the supply of sufficient O2 to the tissues is a major physiological challenge. In mammals, a deficit of O2 (hypoxia) triggers rapid cardiorespiratory reflexes (e.g. hyperventilation and… read more here.
Keywords: mitochondrial acute; oxygen sensing; oxygen; sensing signaling ... See more keywords
Impact of quorum sensing signaling molecules in gram-negative bacteria on host cells: current understanding and future perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2039048
Abstract: ABSTRACT Quorum sensing is a molecular signaling-based communication mechanism in prokaryotes. In the basic mode, signaling molecules released by certain bacteria are sensed by intracellular receptors or membrane-bound receptors of other members in the community,… read more here.
Keywords: signaling molecules; host cells; sensing signaling; quorum sensing ... See more keywords
The systems biology of uric acid transporters: the role of remote sensing and signaling
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000427
Abstract: Purpose of review Uric acid homeostasis in the body is mediated by a number of SLC and ABC transporters in the kidney and intestine, including several multispecific ‘drug’ transporters (e.g., OAT1, OAT3, and ABCG2). Optimization… read more here.
Keywords: uric acid; acid transporters; remote sensing; biology ... See more keywords
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-030322-084058
Abstract: The coordinated movement of organic anions (e.g., drugs, metabolites, signaling molecules, nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends, in large part, on organic anion transporters (OATs) [solute carrier 22 (SLC22)], organic… read more here.
Keywords: toxicology; remote sensing; signaling theory; pharmacology ... See more keywords
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway
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DOI: 10.26508/lsa.202101191
Abstract: Cellular RNA transcripts in endothelial cells, especially the SINE RNAs, need extensive editing by the A-to-I RNA editing enzyme ADAR1, which is essential for neonatal survival by regulating the MDA-5–mediated RNA-sensing signaling pathway. The RNA-sensing… read more here.
Keywords: rna editing; sensing signaling; signaling pathway; mda ... See more keywords
Sensing and Signaling of Methionine Metabolism
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DOI: 10.3390/metabo11020083
Abstract: Availability of the amino acid methionine shows remarkable effects on the physiology of individual cells and whole organisms. For example, most cancer cells, but not normal cells, are hyper dependent on high flux through metabolic… read more here.
Keywords: methionine; signaling methionine; methionine metabolism; physiology ... See more keywords
Impact of Pseudomonas aeruginosa quorum sensing signaling molecules on adhesion and inflammatory markers in endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.14.235
Abstract: Pseudomonas aeruginosa relies on the quorum sensing (QS) signaling system as a central regulator mechanism of virulence expression that contributes to the formation and maintenance of biofilms and tolerance to conventional antimicrobials. QS Signaling molecules… read more here.
Keywords: pseudomonas aeruginosa; adhesion; quorum sensing; expression ... See more keywords