A scenario for the origin of life: Volume regulation by bacteriorhodopsin required extremely voltage sensitive Na‐channels and very selective K‐channels
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100210
Abstract: The osmotic activity produced by internal, non‐permeable, anionic nucleic acids and metabolites causes a persistent and life‐threatening cell swelling, or cellular edema, produced by the Gibbs‐Donnan effect. This evolutionary‐critical osmotic challenge must have been resolved… read more here.
Keywords: voltage sensitive; sensitive channels; bacteriorhodopsin; volume ... See more keywords
PLCβ-Mediated Depletion of PIP2 and ATP-Sensitive K+ Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus
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DOI: 10.1523/eneuro.0120-22.2022
Abstract: Abstract Arginine vasopressin (AVP) serves as a neuromodulator in the brain. The hippocampus is one of the major targets for AVP, as it has been demonstrated that the hippocampus receives vasopressinergic innervation and expresses AVP… read more here.
Keywords: sensitive channels; arginine vasopressin; plc; atp sensitive ... See more keywords
Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O2 Sensitive Voltage-Gated K+ Channels
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DOI: 10.3389/fphar.2018.01518
Abstract: Background: The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are… read more here.
Keywords: pulmonary hypertension; mechanism; receptor; sensitive channels ... See more keywords
The Involvement of NO–cGMP–ATP Sensitive K+ Channels Pathway in Protocatechuic Acid Peripheral Analgesia
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Pharmaceutical Education and Research"
DOI: 10.5530/ijper.51.3s.46
Abstract: Protocatechuic acid (PCA) is a widely distributed natural bioactive phenolic acid. The various pharmacological activities such as antioxidant, antidiabetic and anti-inflammatory activities have been identified. However, the studies focused on the analgesic effect of protocatechuic… read more here.
Keywords: cgmp atp; atp sensitive; protocatechuic acid; channels pathway ... See more keywords