A modular assembly pH-sensitive charge reversal siRNA delivery system.
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DOI: 10.1039/c8bm01062e
Abstract: Cationic lipids and polymers are the most common non-viral vectors for siRNA delivery; however, their intense positively charged character may give rise to serum-triggered aggregation, immune activation, inflammation stimulation and grievous toxicity. An ocean of… read more here.
Keywords: charge reversal; sirna delivery; modular assembly; delivery ... See more keywords
A Systematic Study of Anti-Osteosarcoma Mechanism of pH-Sensitive Charge-Conversion Cinnamaldehyde Polymeric Prodrug Micelles In Vitro
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DOI: 10.3390/biomedicines11061524
Abstract: Osteosarcoma is an aggressive malignant neoplasm, and it is of great significance to the fabrication and investigation of the anti-tumor mechanism of nanomedicine in the treatment of osteosarcoma. Herein, a cinnamaldehyde polymeric prodrug micelle with… read more here.
Keywords: cinnamaldehyde polymeric; polymeric prodrug; mechanism; charge conversion ... See more keywords