Metabolic and immune-sensitive contacts between lipid droplets and endoplasmic reticulum reconstituted in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200513119
Abstract: Significance The intricate membranous network inside cells, with the endoplasmic reticulum (ER) at its center, allows coordinated cellular function by transmitting information across membrane contact sites (MCSs) that form between diverse kinds of cellular organelles… read more here.
Keywords: metabolic immune; endoplasmic reticulum; lipid droplets; sensitive contacts ... See more keywords
Temperature-sensitive contacts in disordered loops tune enzyme I activity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.06.18.496683
Abstract: Homologous enzymes with identical folds often exhibit different thermal and kinetic behaviors. Understanding how enzyme sequence encodes catalytic activity at functionally optimal temperatures is a fundamental problem in biophysics. Recently it was shown that the… read more here.
Keywords: enzyme activity; temperature; disordered loops; activity ... See more keywords