When used together SS18–SSX fusion‐specific and SSX C‐terminus immunohistochemistry are highly specific and sensitive for the diagnosis of synovial sarcoma and can replace FISH or molecular testing in most cases
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DOI: 10.1111/his.14190
Abstract: Synovial sarcoma is defined by recurrent t(X;18)(p11;q11) translocations creating SS18–SSX1, SS18–SSX2 or SS18–SSX4 fusions. Recently, a novel rabbit monoclonal antibody designed to identify these fusions (SS18–SSX, clone E9X9V) was proposed to be highly specific (100%),… read more here.
Keywords: sensitive diagnosis; synovial sarcoma; highly specific; ss18 ssx ... See more keywords
Sensitive diagnosis of paucibacillary tuberculosis with targeted next-generation sequencing: a molecular diagnostic study
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DOI: 10.1186/s12916-025-03996-1
Abstract: Targeted next-generation sequencing (tNGS) enables high-performance tuberculosis (TB) diagnosis and drug resistance prediction directly from clinical samples. However, its applicability to paucibacillary TB, including pediatric TB and extrapulmonary TB (EPTB), has been less explored. We… read more here.
Keywords: diagnosis; generation sequencing; next generation; targeted next ... See more keywords