Evaluation of the pathophysiological mechanisms of salt-sensitive hypertension
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DOI: 10.1038/s41440-019-0332-5
Abstract: The currently available data have indicated that dietary salt is directly correlated with blood pressure (BP) and the occurrence of hypertension. However, the salt sensitivity of BP is different in each individual. Genetic factors and… read more here.
Keywords: salt; sensitive hypertension; salt sensitive; hypertension ... See more keywords
The WNK signaling pathway and salt-sensitive hypertension
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DOI: 10.1038/s41440-020-0437-x
Abstract: The distal nephron of the kidney has a central role in sodium and fluid homeostasis, and disruption of this homeostasis due to mutations of with-no-lysine kinase 1 (WNK1), WNK4, Kelch-like 3 (KLHL3), or Cullin 3… read more here.
Keywords: sensitive hypertension; wnk signaling; signaling pathway; salt sensitive ... See more keywords
A1899 Antagonizing salt-sensitive hypertension by caffeine intake through promotion of CFTR-mediated intestinal secretion of Cl−
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DOI: 10.1097/01.hjh.0000548011.55993.14
Abstract: Objectives: The intestine plays an important part in sodium absorption. Chronic intake of caffeine has been reported to attenuate salt-sensitive hypertension through promotion of excretion of urinary sodium. We investigated if chronic consumption of caffeine… read more here.
Keywords: secretion; cftr; caffeine; sensitive hypertension ... See more keywords
A1990 Novel mechanism of salt-sensitive hypertension: CD8 T cells stimulate sodium chloride co-transporter in the kidney
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DOI: 10.1097/01.hjh.0000548024.68562.fa
Abstract: Objectives: The kidney plays a key role in salt-sensitive hypertension. Recent studies also suggest a role for T lymphocytes in hypertension. However, whether T cells contribute to renal sodium retention is an important question, which… read more here.
Keywords: novel mechanism; sodium; sensitive hypertension; salt sensitive ... See more keywords
FBLN2 Abates Epigenetic-mediated Salt-sensitive Hypertension Through Regulation of NCC Trafficking
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DOI: 10.1152/physiol.2023.38.s1.5729401
Abstract: Epigenetics play a role in the development of hypertension. However, the precise mechanisms of how histone modification in renal tubule cells regulates blood pressure is largely undiscovered. In this study, we investigated the role of… read more here.
Keywords: kdm6a cko; hypertension; sensitive hypertension; physiology ... See more keywords
Divergent Sex-Specific Effects of Toll-like Receptor 4 and Cluster of Differentiation 14 in Dahl Salt-Sensitive Hypertension
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DOI: 10.1152/physiol.2023.38.s1.5734225
Abstract: Renal inflammation accompanies hypertension and renal damage in Dahl Salt-Sensitive rats fed a high salt diet (HS, 4.0% NaCl). Via a transcriptomics approach, we previously found cluster of differentiation 14 (CD14) and toll-like receptor 4… read more here.
Keywords: physiology; sensitive hypertension; salt sensitive; dahl ... See more keywords
DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension
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DOI: 10.1161/circresaha.122.320818
Abstract: Background: Salt sensitivity of blood pressure is an independent predictor of cardiovascular morbidity and mortality. The exact mechanism by which salt intake increases blood pressure and cardiovascular risk is unknown. We previously found that sodium… read more here.
Keywords: sensitive hypertension; sodium; inflammasome activation; salt sensitive ... See more keywords
Abstract 053: Dietary Sodium Restriction versus Diuretics for Salt-Sensitive Hypertension in Chronic Kidney Disease
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DOI: 10.1161/hyp.72.suppl_1.053
Abstract: Fluid overload and salt-sensitive hypertension are hallmarks of advanced chronic kidney disease (CKD) and associated with worse outcomes. Dietary sodium (Na+) restriction is an accepted interventio... read more here.
Keywords: dietary sodium; chronic kidney; sensitive hypertension; salt sensitive ... See more keywords
Abstract P131: Jak2 Expression In Cd11c+ Myeloid Cells Plays A Role In Salt-sensitive Hypertension Through An Enac-dependent Mechanism.
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DOI: 10.1161/hyp.76.suppl_1.p131
Abstract: Hypertension is a major risk factor for development of cardiovascular disease. Excess dietary salt contributes to inflammation and the genesis of hypertension. We recently found that gamma and alpha subunits of the epithelial sodium channel… read more here.
Keywords: cd11c; salt; sensitive hypertension; salt sensitive ... See more keywords
Epithelial Sodium Channel and Salt-Sensitive Hypertension.
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DOI: 10.1161/hypertensionaha.120.14481
Abstract: The development of high blood pressure is influenced by genetic and environmental factors, with high salt intake being a known environmental contributor. Humans display a spectrum of sodium-sensitivity, with some individuals displaying a significant blood… read more here.
Keywords: epithelial sodium; sodium; sensitive hypertension; salt sensitive ... See more keywords
Gut-Immune-Kidney Axis: Influence of Dietary Protein in Salt-Sensitive Hypertension.
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DOI: 10.1161/hypertensionaha.122.18556
Abstract: Humans with salt-sensitive hypertension demonstrate increased morbidity, increased mortality, and renal end-organ damage when compared with normotensive subjects or those with salt-resistant hypertension. Substantial evidence from humans and animals has also demonstrated the role of… read more here.
Keywords: hypertension; sensitive hypertension; salt sensitive; hypertension gut ... See more keywords