Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.
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DOI: 10.1016/j.celrep.2022.110622
Abstract: The tumor suppressor p53 is inactivated by over hundreds of heterogenous mutations in cancer. Here, we purposefully selected phenotypically reversible temperature-sensitive (TS) p53 mutations for pharmacological rescue with thermostability as the compound-screening readout. This rational… read more here.
Keywords: antiparasitic antimonials; sensitive p53; p53 mutations; temperature sensitive ... See more keywords