Psychotropic Effects of a New Pyrazolo[C]Pyridine Derivate GIZh-72 are Related to Functional Activity of Atp-Sensitive Potassium Channels
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-020-04729-5
Abstract: We studied the influence of intraperitoneal injection of ATP-sensitive potassium channels inhibitor glibenclamide in doses of 0.01, 0.1, 1, and 10 mg/kg on the effects of a new pyrazolo[C]pyridine derivative GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,3-dihydro-1Hpyrazolo[ 4,3-C]pyridine-3-on, chloral hydrate;… read more here.
Keywords: potassium channels; sensitive potassium; effects new; atp sensitive ... See more keywords
Preconditioning by Levosimendan is Mediated by Activation of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-018-6819-5
Abstract: PurposeActivation of mitochondrial large-conductance Ca2+-sensitive potassium (mBKCa)-channels is a crucial step for cardioprotection by preconditioning. Whether activation of these channels is involved in levosimendan-induced preconditioning is unknown. We investigated if cardioprotection by levosimendan requires activation… read more here.
Keywords: levosimendan; sensitive potassium; mbkca channels; mbkca ... See more keywords
A novel carbazole-based hydrogen-sulfide donor suppresses seizures and upregulates ATP-sensitive potassium channels
Sign Up to like & getrecommendations! Published in 2020 at "Applied Materials Today"
DOI: 10.1016/j.apmt.2020.100559
Abstract: Abstract Epilepsy is characterized by repeated spontaneous seizures and remains untreatable due to its complicate pathogenesis. Low-dose hydrogen sulfide (H2S) has been shown to exert antiepileptic and protective effects in the central nervous system, but… read more here.
Keywords: sensitive potassium; h2s donor; carbazole based; atp sensitive ... See more keywords
Therapeutic potential of ATP-sensitive potassium channels in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.01.003
Abstract: In the past decade, there was an increasing interest in the therapeutic potential targeting ATP-sensitive potassium (KATP) channels for an effective treatment of Parkinson's disease (PD). KATP channels are widely expressed in the central nervous… read more here.
Keywords: sensitive potassium; katp channels; atp sensitive; parkinson disease ... See more keywords
Mechanistic Pathways of ATP Sensitive Potassium Channels Referring to Cardio-Protective Effects and Cellular Functions.
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DOI: 10.1055/a-0806-7207
Abstract: A study of potassium channels correlates the fundamentals of mechanistic pathways and various physiological functions. The knowledge of these pathways provides the background, how to determine unit cell functions and to affect cardio protection. ATP… read more here.
Keywords: potassium channels; potassium; sensitive potassium; atp sensitive ... See more keywords
Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats.
Sign Up to like & getrecommendations! Published in 2023 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2023.2201659
Abstract: BACKGROUND Methotrexate (MTX) is a commonly used chemotherapeutic agent; however, its clinical use is challenged by various types of injuries, including hepatotoxic side effects. Therefore, finding new protective drugs against MTX-induced toxicities is a critical… read more here.
Keywords: enos glycoprotein; liver injury; atp sensitive; potassium channel ... See more keywords
Trapping endoplasmic reticulum with amphiphilic AIE-active sensor via specific interaction of ATP-sensitive potassium (KATP)
Sign Up to like & getrecommendations! Published in 2021 at "National Science Review"
DOI: 10.1093/nsr/nwaa198
Abstract: Abstract The current aggregation-induced emission luminogens (AIEgens) sometimes suffer from poor targeting selectivity due to undesirable aggregation in the hydrophilic biosystem with ‘always-on’ fluorescence or unspecific aggregation in the lipophilic organelle with prematurely activated fluorescence.… read more here.
Keywords: aggregation; sensitive potassium; endoplasmic reticulum; potassium katp ... See more keywords
Involvement of adenosine triphosphate-sensitive potassium channels in the neuroprotective activity of hydrogen sulfide in the 6-hydroxydopamine-induced animal model of Parkinson’s disease
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DOI: 10.1097/fbp.0000000000000358
Abstract: Studies have shown that hydrogen sulfide (H2S) exerts a neuroprotective effect and may have a therapeutic value for treating neurodegenerative diseases including Parkinson's disease. However, little is known about the mechanisms underlying the neuroprotective activity… read more here.
Keywords: sensitive potassium; animal model; parkinson; parkinson disease ... See more keywords
Extracranial activation of ATP-sensitive potassium channels induces vasodilation without nociceptive effects
Sign Up to like & getrecommendations! Published in 2019 at "Cephalalgia"
DOI: 10.1177/0333102419888490
Abstract: Introduction Levcromakalim opens ATP-sensitive potassium channels (KATP channel) and induces head pain in healthy volunteers and migraine headache in migraine patients, but no pain in other parts of the body. KATP channels are expressed in… read more here.
Keywords: potassium channels; sensitive potassium; placebo forehead; atp sensitive ... See more keywords
Ca2+-Sensitive Potassium Channels
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DOI: 10.3390/molecules28020885
Abstract: The Ca2+ ion is used ubiquitously as an intracellular signaling molecule due to its high external and low internal concentration. Many Ca2+-sensing ion channel proteins have evolved to receive and propagate Ca2+ signals. Among them… read more here.
Keywords: potassium channels; ca2 activated; ca2 sensitive; sensitive potassium ... See more keywords
Modulatory Effect of Medicinal Plants and Their Active Constituents on ATP-Sensitive Potassium Channels (KATP) in Diabetes
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DOI: 10.3390/ph16040523
Abstract: Hyperglycemia, which is a chronic metabolic condition caused by either a defect in insulin secretion or insulin resistance, is a hallmark of diabetes mellitus (DM). Sustained hyperglycemia leads to the onset and development of many… read more here.
Keywords: active constituents; potassium channels; atp sensitive; plants active ... See more keywords