Sensitive Top-Down Proteomics Analysis of a Low Number of Mammalian Cells Using a Nanodroplet Sample Processing Platform.
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DOI: 10.1021/acs.analchem.0c00467
Abstract: Top-down proteomics is a powerful tool for characterizing genetic variations and post-translational modifications at intact protein level. However, one significant technical gap of top-down proteomics is the inability to analyze a low amount of biological… read more here.
Keywords: sample; proteomics analysis; sensitive top; platform ... See more keywords