Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice.
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DOI: 10.1016/j.abb.2018.11.006
Abstract: Mutations in cardiac troponin T (TnT) associated with hypertrophic cardiomyopathy generally lead to an increase in the Ca2+ sensitivity of contraction and susceptibility to arrhythmias. In contrast, TnT mutations linked to dilated cardiomyopathy decrease the… read more here.
Keywords: het; ca2 sensitivity; myofilament ca2; sensitivity ... See more keywords