Site-Directed Mutagenesis of the 1,3-β-Glucan Synthase Catalytic Subunit of Pneumocystis jirovecii and Susceptibility Assays Suggest Its Sensitivity to Caspofungin
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DOI: 10.1128/aac.01159-18
Abstract: The echinocandin caspofungin inhibits the catalytic subunit Gsc1 of the enzymatic complex synthesizing 1,3-β-glucan, an essential compound of the fungal wall. Studies with rodents showed that caspofungin is effective against Pneumocystis asci. ABSTRACT The echinocandin… read more here.
Keywords: pneumocystis; caspofungin; sensitivity caspofungin; catalytic subunit ... See more keywords