A lncRNA Decoy Predicts Sensitivity to Cisplatin.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2020.01.015
Abstract: In a recent iScience paper by Fan et al., the long noncoding (lnc)RNA CISAL is shown to form a DNA-RNA triplex and to directly regulate BRCA1 transcription, thereby increasing cisplatin sensitivity and serving as a… read more here.
Keywords: decoy predicts; lncrna decoy; cisplatin; sensitivity cisplatin ... See more keywords
Knockdown of the oncogene lncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in osteosarcoma
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DOI: 10.1042/bsr20180375
Abstract: Aberrant expressions of long non-coding RNAs (lncRNAs) are the culprits of carcinogenesis via regulating the tumor suppressor or oncogene. LncRNA nuclear enriched abundant transcript 1 (NEAT1) has been identified to be an oncogene to promote… read more here.
Keywords: tumor; oncogene lncrna; sensitivity cisplatin; mir 34c ... See more keywords
Up-regulation of microRNA miR-101-3p enhances sensitivity to cisplatin via regulation of small interfering RNA (siRNA) Anti-human AGT4D and autophagy in non-small-cell lung carcinoma (NSCLC).
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1982274
Abstract: The emergence of drug resistance hinders the treatment of malignant tumors, and autophagy plays an important role in tumor chemotherapy resistance. However, its mechanism in non-small cell lung cancer (NSCLC) has not been well-researched. We… read more here.
Keywords: atg4d; mir 101; sensitivity cisplatin; non small ... See more keywords
Abstract 1323: A p53-dependent switch between cytoprotective and nonprotective autophagy influences tumor cell sensitivity to cisplatin
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1323
Abstract: Autophagy is a multi-step, homeostatic process through which cells turnover dysfunctional organelles and proteins. Previous work in our laboratory has identified multiple functional roles of autophagy, specifically cytoprotective, cytotoxic, cytostatic and nonprotective, when subjected to… read more here.
Keywords: sensitivity cisplatin; p53; switch; autophagy ... See more keywords
Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin
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DOI: 10.18632/oncotarget.13353
Abstract: Ovarian, head and neck, and other cancers are commonly treated with cisplatin and other DNA damaging cytotoxic agents. Altered DNA damage response (DDR) contributes to resistance of these tumors to chemotherapies, some targeted therapies, and… read more here.
Keywords: dna damage; damage response; cisplatin; sensitivity cisplatin ... See more keywords