Bioluminescence Goes Dark: Boosting the Performance of Bioluminescent Sensor Proteins Using Complementation Inhibitors
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DOI: 10.1021/acssensors.2c01726
Abstract: Bioluminescent sensor proteins have recently gained popularity in both basic research and point-of-care diagnostics. Sensor proteins based on intramolecular complementation of split NanoLuc are particularly attractive because their intrinsic modular design enables for systematic tuning… read more here.
Keywords: performance bioluminescent; complementation; bioluminescent sensor; sensor proteins ... See more keywords
Semisynthetic sensor proteins enable metabolic assays at the point of care
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DOI: 10.1126/science.aat7992
Abstract: A protein designed to sense metabolites Many diseases cause characteristic changes in blood metabolites. Yu et al. describe a paper-based assay in which a chosen metabolite can be oxidized to generate reduced nicotinamide adenine dinucleotide… read more here.
Keywords: point care; sensor; sensor proteins; metabolic assays ... See more keywords
Zinc Modulation of Neuronal Calcium Sensor Proteins: Three Modes of Interaction with Different Structural Outcomes
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DOI: 10.3390/biom12070956
Abstract: Neuronal calcium sensors (NCSs) are the family of EF-hand proteins mediating Ca2+-dependent signaling pathways in healthy neurons and neurodegenerative diseases. It was hypothesized that the calcium sensor activity of NCSs can be complemented by sensing… read more here.
Keywords: neuronal calcium; calcium; affinity; sensor proteins ... See more keywords