Effect of gabapentin on sleep-deprivation-induced disruption of prepulse inhibition
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DOI: 10.1007/s00213-020-05587-9
Abstract: There are controversial reports on the effects of gabapentin in respect to psychotic symptoms. Prepulse inhibition of the acoustic startle response is an operational measure of sensorimotor gating. In laboratory rodents, deficits in sensorimotor gating… read more here.
Keywords: sleep deprivation; sensorimotor gating; deprivation; prepulse inhibition ... See more keywords
The adenosine A(2A) receptor agonist CGS 21680 alleviates auditory sensorimotor gating deficits and increases in accumbal CREB in rats neonatally treated with quinpirole
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DOI: 10.1007/s00213-020-05631-8
Abstract: The adenosine A(2A) receptor forms a mutually inhibitory heteromer with the dopamine D2 receptor, and A(2A) agonists decrease D2 signaling. This study analyzed whether an adenosine A(2A) agonist would alleviate deficits in sensorimotor gating and… read more here.
Keywords: agonist; sensorimotor gating; cgs 21680; adenosine receptor ... See more keywords
Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti rats
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DOI: 10.1007/s00213-020-05751-1
Abstract: Rationale Calcineurin is a protein regulating cytokine expression in T lymphocytes and calcineurin inhibitors such as cyclosporine A (CsA) are widely used for immunosuppressive therapy. It also plays a functional role in distinct neuronal processes… read more here.
Keywords: calcineurin; dark agouti; sensorimotor gating; treatment ... See more keywords
Disrupted sensorimotor gating in first-episode psychosis patients is not affected by short-term antipsychotic treatment
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DOI: 10.1016/j.schres.2020.12.009
Abstract: BACKGROUND Impaired sensorimotor gating, commonly measured as disrupted prepulse inhibition (PPI) of the acoustic startle response, has been widely observed in psychotic diseases. However, most PPI studies published so far involve patients with long illness… read more here.
Keywords: sensorimotor gating; treatment; first episode; episode psychosis ... See more keywords
Dopamine Receptor Blockade Attenuates Purinergic P2X4 Receptor-Mediated Prepulse Inhibition Deficits and Underlying Molecular Mechanisms
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DOI: 10.3389/fncel.2019.00331
Abstract: Sensorimotor gating refers to the ability to filter incoming sensory information in a stimulus-laden environment and disruption of this physiological process has been documented in psychiatric disorders characterized by cognitive aberrations. The effectiveness of current… read more here.
Keywords: ppi deficits; sensorimotor gating; prepulse inhibition; receptor ... See more keywords
Genetic Determinants of Gating Functions: Do We Get Closer to Understanding Schizophrenia Etiopathogenesis?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2020.550225
Abstract: Deficits in the gating of sensory stimuli, i.e., the ability to suppress the processing of irrelevant sensory input, are considered to play an important role in the pathogenesis of several neuropsychiatric disorders, in particular schizophrenia.… read more here.
Keywords: genetic determinants; schizophrenia; gating functions; sensorimotor gating ... See more keywords