Inhibition of inflammatory osteoclasts accelerates callus remodeling in osteoporotic fractures by enhancing CGRP+TrkA+ signaling
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-024-01368-5
Abstract: Impaired callus remodeling significantly contributes to the delayed healing of osteoporotic fractures; however, the underlying mechanisms remain unclear. Sensory neuronal signaling plays a crucial role in bone repair. In this study, we aimed to investigate… read more here.
Keywords: callus remodeling; osteoporotic fractures; sensory neuronal; remodeling osteoporotic ... See more keywords
Sensory neuronal P2RX4 receptors controls BDNF signaling in inflammatory pain
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-19301-5
Abstract: Chronic inflammatory and neuropathic pains are major public health concerns. Potential therapeutic targets include the ATP-gated purinergic receptors (P2RX) that contribute to these pathological types of pain in several different cell types. The purinergic receptors… read more here.
Keywords: p2rx4; sensory neuronal; inflammatory pain; chronic inflammatory ... See more keywords
OR23-06 Sensory neuronal ACVR1-mediated neuroimmune contribution to neuropathic pain and heterotopic ossification in fibrodysplasia ossificans progressiva
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.565
Abstract: Abstract Disclosure: X. Yu: None. J. Braz: None. L. Lam: None. K. Bhardwaji: None. K. Jin: None. H. Yuan: None. D. Mohsenin: None. E. Yu: None. J. Weinrich: None. B. Ahanonu: None. A. Basbaum: None.… read more here.
Keywords: none; contribution; pain; sensory neuronal ... See more keywords