Demyelination in hereditary sensory neuropathy type‐1C
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DOI: 10.1002/acn3.51110
Abstract: Sphingolipids are enriched in the nerves. Serine‐palmitoyltransferase (SPT) catalyzes the key step of sphingolipids biosynthesis. Mutations in SPT subunits (SPTLC) lead to the excessive production of neurotoxic deoxysphingolipids (DoxSLs) in patients with Hereditary Sensory Neuropathy… read more here.
Keywords: sensory neuropathy; pathology; hereditary sensory; demyelination hereditary ... See more keywords
Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated without stavudine
Sign Up to like & getrecommendations! Published in 2019 at "Journal of NeuroVirology"
DOI: 10.1007/s13365-019-00771-w
Abstract: HIV-associated sensory neuropathy (HIV-SN) is a debilitating neurological complication of HIV infection potentiated by the antiretroviral drug stavudine. While stavudine is no longer used, HIV-SN now affects around 15% of HIV+ Indonesians. Here, we investigate… read more here.
Keywords: polymorphisms camkk2; hiv patients; hiv; neuropathy hiv ... See more keywords
Effects of orthopedic footwear on postural stability and walking in individuals with Hereditary Motor Sensory Neuropathy.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical biomechanics"
DOI: 10.1016/j.clinbiomech.2022.105638
Abstract: BACKGROUND Orthopedic footwear is often prescribed to improve postural stability during standing and walking in individuals with Hereditary Motor Sensory Neuropathy. However, supporting evidence in literature is scarce. The aim of this study was to… read more here.
Keywords: individuals hereditary; orthopedic footwear; sensory neuropathy; motor sensory ... See more keywords
Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy
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DOI: 10.1038/s41598-017-03825-3
Abstract: The human chaperonin TRiC consists of eight non-identical subunits, and its protein-folding activity is critical for cellular health. Misfolded proteins are associated with many human diseases, such as amyloid diseases, cancer, and neuropathies, making TRiC… read more here.
Keywords: cct subunit; sensory neuropathy; associated hereditary; human tric ... See more keywords
Calcium-Mediated Calpain Activation and Microtubule Dissociation in Cell Model of Hereditary Sensory Neuropathy Type-1 Expressing V144D SPTLC1 Mutation.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2021.0816
Abstract: Hereditary sensory neuropathy type 1A (HSN1A) is an autosomal, dominantly inherited peripheral neuropathy caused by mutations in serine palmitoyl transferase long chain 1 (SPTLC1), involved in the de novo synthesis of sphingolipids. We have previously… read more here.
Keywords: cell; hereditary sensory; cell model; neuropathy type ... See more keywords
Novel MFN2 Missense Mutation Induces Hereditary Axonal Motor and Sensory Neuropathy in a Saudi Arabian Family.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuromuscular Disease"
DOI: 10.1097/cnd.0000000000000244
Abstract: Hereditary axonal motor and sensory neuropathy or Charcot-Marie-Tooth type 2 (CMT2) is a common inherited peripheral neuropathy. Major symptomatologic signs vary from minimal to significant weakness and loss of sensation, feet usually affected more than… read more here.
Keywords: sensory neuropathy; saudi arabian; axonal motor; motor sensory ... See more keywords
Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated painful sensory neuropathy
Sign Up to like & getrecommendations! Published in 2018 at "Pain Reports"
DOI: 10.1097/pr9.0000000000000654
Abstract: Introduction: HIV infection is associated with chronic pain states, including sensory neuropathy, which affects greater than 40% of patients. Objectives and Methods: To determine the impact of HIV-Tat induction on nociceptive behaviour in female mice… read more here.
Keywords: sensory; tat induction; hiv; intraepidermal nerve ... See more keywords
Sensory neuropathy in progressive motor neuronopathy (pmn) mice is associated with defects in microtubule polymerization and axonal transport
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DOI: 10.1111/bpa.12422
Abstract: Motor neuron diseases such as amyotrophic lateral sclerosis (ALS) are now recognized as multi‐system disorders also involving various non‐motor neuronal cell types. The precise extent and mechanistic basis of non‐motor neuron damage in human ALS… read more here.
Keywords: transport; sensory neuropathy; motor; mice ... See more keywords
Arterial Stiffness Is Associated with Peripheral Sensory Neuropathy in Diabetes Patients in Ghana
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DOI: 10.1155/2018/2320737
Abstract: Objective Peripheral sensory neuropathy (PSN) is among microvascular complications of diabetes that make patients prone to ulceration and amputation. Arterial stiffness is a predictor of cardiovascular diseases and microvascular complications associated with diabetes. We investigated… read more here.
Keywords: peripheral sensory; sensory neuropathy; arterial stiffness; diabetes patients ... See more keywords
Magnitude of peripheral sensory neuropathy and associated factors among HIV/AIDS clients receiving care at public health institutions, Northwest Ethiopia
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DOI: 10.1177/17448069221089593
Abstract: Background: In the mid-1990s, the development of combination antiretroviral therapy converted HIV infection into a chronic condition, with newly diagnosed patients now living longer than the general population. HIV affects both the central and peripheral… read more here.
Keywords: public health; peripheral sensory; sensory neuropathy; health institutions ... See more keywords
Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy
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DOI: 10.1371/journal.pone.0204111
Abstract: Background The use of the HIV antiretroviral drug stavudine (d4T), a thymidine analogue, is associated with the development of mitochondrial toxicities such as sensory neuropathy (SN). Genetic variation in genes relating to d4T transport and… read more here.
Keywords: variation; d4t; sensory neuropathy; occurrence ... See more keywords