Discovery of a Class of Potent and Selective Non‐competitive Sentrin‐Specific Protease 1 Inhibitors
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DOI: 10.1002/cmdc.202000067
Abstract: Sentrin‐specific proteases (SENPs) are responsible for the maturation of small ubiquitin‐like modifiers (SUMOs) and the deconjugation of SUMOs from their substrate proteins. Studies on prostate cancer revealed an overexpression of SENP1, which promotes prostate cancer… read more here.
Keywords: discovery class; potent selective; prostate cancer; sentrin specific ... See more keywords
The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis
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DOI: 10.1038/s41598-018-28103-8
Abstract: Smad4, a common-mediator of Smads, plays a central role in forming complexes with receptor-phosphorylated Smads, and then transduces transforming growth factor (TGF)-β signals into the nuclei. Although many cellular factors are involved in TGF-β induced… read more here.
Keywords: sentrin specific; cell migration; specific protease; tgf ... See more keywords