Securin-independent regulation of separase by checkpoint-induced shugoshin–MAD2
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2182-3
Abstract: Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion-mediating cohesin 1 – 3 . Silencing of the SAC during metaphase… read more here.
Keywords: separase; securin; shugoshin mad2; checkpoint ... See more keywords
Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1906237116
Abstract: Significance Accurate chromosome segregation at mitosis and meiosis is crucial to prevent genome instability, birth defect, and cancer. Accordingly, separase, the protease that triggers chromosome distribution, is tightly regulated by a direct inhibitor, the securin.… read more here.
Keywords: pans1; separase; securin; plant securin ... See more keywords
Separase prevents genomic instability by controlling replication fork speed
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1172
Abstract: Abstract Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development. Sister chromatid separation is triggered by Separase, an evolutionary conserved protease… read more here.
Keywords: controlling replication; genomic instability; separase; fork ... See more keywords
Biology and insights into the role of cohesin protease separase in human malignancies
Sign Up to like & getrecommendations! Published in 2017 at "Biological Reviews"
DOI: 10.1111/brv.12321
Abstract: Separase, an enzyme that resolves sister chromatid cohesion during the metaphase‐to‐anaphase transition, plays a pivotal role in chromosomal segregation and cell division. Separase protein, encoded by the extra spindle pole bodies like 1 (ESPL1) gene,… read more here.
Keywords: separase; insights role; biology; biology insights ... See more keywords
Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007029
Abstract: Anaphase onset is an irreversible cell cycle transition that is triggered by the activation of the protease Separase. Separase cleaves the Mcd1 (also known as Scc1) subunit of Cohesin, a complex of proteins that physically… read more here.
Keywords: anaphase; separase; esp1; cohesin ... See more keywords
Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.2139/ssrn.4125670
Abstract: Accurate chromosome segregation requires timely activation of separase, a protease that cleaves cohesin during the metaphase-to-anaphase transition. However, the mechanism that maintains the inactivity of separase prior to this event remains unclear. We provide evidence… read more here.
Keywords: separase autocleavage; autocleavage; separase; binding cyclin ... See more keywords