lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-0572-2
Abstract: Cooperation between DNA, RNA and protein regulates gene expression and controls differentiation through interactions that connect regions of nucleic acids and protein domains and through the assembly of biomolecular condensates. Here, we report that endoderm… read more here.
Keywords: protein; endoderm differentiation; brd3; differentiation ... See more keywords
Preprint Highlight: The selective autophagy receptor p62 and the heat shock protein HSP27 facilitate lysophagy via the formation of phase-separated condensates.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-08-1003
Abstract: Ruptured lysosomes are cleared by lysophagy, a selective form of macroautophagy. Thus lysophagy protects cells against lysosomal cell death, a form of cell death caused by the release of lysosomal proteases to the cytosol from… read more here.
Keywords: separated condensates; hsp27; formation; p62 ... See more keywords
Partitioning into Phase-Separated Condensates Mediates Drug Activity.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-096
Abstract: Anticancer drugs' ability to concentrate in condensates containing their targets affected activity. read more here.
Keywords: partitioning phase; condensates mediates; activity; mediates drug ... See more keywords