Phase Separation and Aggregation of α‐Synuclein Diverge at Different Salt Conditions
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DOI: 10.1002/advs.202308279
Abstract: The coacervation of alpha‐synuclein (αSyn) into cytotoxic oligomers and amyloid fibrils are considered pathological hallmarks of Parkinson's disease. While aggregation is central to amyloid diseases, liquid–liquid phase separation (LLPS) and its interplay with aggregation have… read more here.
Keywords: phase separation; salt; separation aggregation; aggregation ... See more keywords
Pathological Involvement of Protein Phase Separation and Aggregation in Neurodegenerative Diseases
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DOI: 10.3390/ijms251810187
Abstract: Neurodegenerative diseases are the leading cause of human disability and immensely reduce patients’ life span and quality. The diseases are characterized by the functional loss of neuronal cells and share several common pathogenic mechanisms involving… read more here.
Keywords: phase separation; separation aggregation; aggregation; neurodegenerative diseases ... See more keywords