Early Sepsis-Associated Acute Kidney Injury and Obesity
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.54923
Abstract: This cohort study explores the association between obesity and sepsis-associated acute kidney injury and clinical outcomes among intensive care unit patients in Korea. read more here.
Keywords: obesity; associated acute; kidney injury; acute kidney ... See more keywords
AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205862
Abstract: The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism causing cognitive impairment.… read more here.
Keywords: associated encephalopathy; cognitive impairment; sepsis associated; astrocyte ... See more keywords
Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507411
Abstract: Sepsis‐associated pulmonary fibrosis (SAPF) is a life‐threatening condition driven by persistent fibroblast activation and excessive extracellular matrix (ECM) deposition. While metabolic reprogramming, profibrotic extracellular vesicles (EVs), and integrin activation are implicated in pulmonary fibrosis, their… read more here.
Keywords: associated pulmonary; activation; transfer; pulmonary fibrosis ... See more keywords
Neuroprotective effects of annexin A1 tripeptide in rats with sepsis‐associated encephalopathy
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2569
Abstract: Sepsis‐associated encephalopathy (SAE) is characterized by high incidence and mortality rates, with limited treatment options available. The underlying mechanisms and pathogenesis of SAE remain unclear. Annexin A1 (ANXA1), a membrane‐associated protein, is involved in various… read more here.
Keywords: anxa1sp; sae; group; associated encephalopathy ... See more keywords
Downregulation of lncRNA TUG1 contributes to the development of sepsis‐associated acute kidney injury via regulating miR‐142‐3p/sirtuin 1 axis and modulating NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28409
Abstract: This study intended to investigate the potential molecular mechanism of long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in the development of sepsis‐associated acute kidney injury (AKI). The expression of TUG1 in the serum… read more here.
Keywords: tug1; mir 142; sepsis associated; injury ... See more keywords
Potentially modifiable factors contributing to sepsis-associated encephalopathy
Sign Up to like & getrecommendations! Published in 2017 at "Intensive Care Medicine"
DOI: 10.1007/s00134-017-4807-z
Abstract: PurposeIdentifying modifiable factors for sepsis-associated encephalopathy may help improve patient care and outcomes.MethodsWe conducted a retrospective analysis of a prospective multicenter database. Sepsis-associated encephalopathy (SAE) was defined by a score on the Glasgow coma scale… read more here.
Keywords: factors contributing; associated encephalopathy; sepsis associated; potentially modifiable ... See more keywords
Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Sign Up to like & getrecommendations! Published in 2020 at "Intensive Care Medicine"
DOI: 10.1007/s00134-019-05878-6
Abstract: Objectives To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. Design A panel of 49 international experts, representing 12 international organizations,… read more here.
Keywords: sepsis; septic shock; evidence; sepsis associated ... See more keywords
Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
Sign Up to like & getrecommendations! Published in 2024 at "Intensive Care Medicine"
DOI: 10.1007/s00134-023-07271-w
Abstract: Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidney injury (SA-AKI) patients. REVIVAL, was a… read more here.
Keywords: trial; ilofotase alfa; alkaline phosphatase; sepsis associated ... See more keywords
Short- and Long-Term Protective Effects of Melatonin in a Mouse Model of Sepsis-Associated Encephalopathy
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0708-0
Abstract: Brain dysfunction is a common complication after sepsis and is an independent risk factor for a poor prognosis, which is partly attributed to the dysregulated inflammatory response and oxidative damage. Melatonin regulates the sleep–wake cycle… read more here.
Keywords: sepsis; treatment; dysfunction; sepsis associated ... See more keywords
Astroglia in Sepsis Associated Encephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02743-2
Abstract: Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components… read more here.
Keywords: astroglia sepsis; associated encephalopathy; pathology; sepsis associated ... See more keywords
Morin Ameliorates Lipopolysaccharides-Induced Sepsis-Associated Encephalopathy and Cognitive Impairment in Albino Mice
Sign Up to like & getrecommendations! Published in 2024 at "Neurochemical Research"
DOI: 10.1007/s11064-024-04269-8
Abstract: Sepsis-associated encephalopathy is a common neurological complication of sepsis that is characterized by neuroinflammation, oxidative stress and apoptosis, which results in cognitive impairments in septic survivors. Despite numerous treatment options for this condition, none of… read more here.
Keywords: lipopolysaccharides induced; associated encephalopathy; induced sepsis; morin ... See more keywords