AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205862
Abstract: The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism causing cognitive impairment.… read more here.
Keywords: associated encephalopathy; cognitive impairment; sepsis associated; astrocyte ... See more keywords
Downregulation of lncRNA TUG1 contributes to the development of sepsis‐associated acute kidney injury via regulating miR‐142‐3p/sirtuin 1 axis and modulating NF‐κB pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28409
Abstract: This study intended to investigate the potential molecular mechanism of long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in the development of sepsis‐associated acute kidney injury (AKI). The expression of TUG1 in the serum… read more here.
Keywords: tug1; mir 142; sepsis associated; injury ... See more keywords
Potentially modifiable factors contributing to sepsis-associated encephalopathy
Sign Up to like & getrecommendations! Published in 2017 at "Intensive Care Medicine"
DOI: 10.1007/s00134-017-4807-z
Abstract: PurposeIdentifying modifiable factors for sepsis-associated encephalopathy may help improve patient care and outcomes.MethodsWe conducted a retrospective analysis of a prospective multicenter database. Sepsis-associated encephalopathy (SAE) was defined by a score on the Glasgow coma scale… read more here.
Keywords: factors contributing; associated encephalopathy; sepsis associated; potentially modifiable ... See more keywords
Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Sign Up to like & getrecommendations! Published in 2020 at "Intensive Care Medicine"
DOI: 10.1007/s00134-019-05878-6
Abstract: Objectives To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. Design A panel of 49 international experts, representing 12 international organizations,… read more here.
Keywords: sepsis; septic shock; evidence; sepsis associated ... See more keywords
Short- and Long-Term Protective Effects of Melatonin in a Mouse Model of Sepsis-Associated Encephalopathy
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0708-0
Abstract: Brain dysfunction is a common complication after sepsis and is an independent risk factor for a poor prognosis, which is partly attributed to the dysregulated inflammatory response and oxidative damage. Melatonin regulates the sleep–wake cycle… read more here.
Keywords: sepsis; treatment; dysfunction; sepsis associated ... See more keywords
Astroglia in Sepsis Associated Encephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02743-2
Abstract: Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly characterised. Brain pathology in SAE, which is manifested by impaired perception, consciousness and cognition, results from multifactorial events, including high levels of systemic cytokines, microbial components… read more here.
Keywords: astroglia sepsis; associated encephalopathy; pathology; sepsis associated ... See more keywords
Role of microRNAs As Biomarkers in Sepsis-Associated Encephalopathy
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02445-3
Abstract: Sepsis-associated encephalopathy (SAE) is a neurological complication of sepsis, characterized by brain dysfunction without any direct central nervous system infection. The diagnosis of SAE is currently a challenge. In fact, problems in making a diagnosis… read more here.
Keywords: micrornas biomarkers; diagnosis; associated encephalopathy; sepsis associated ... See more keywords
Impact of chloride-rich crystalloids on sepsis-associated community-acquired acute kidney injury recovery in critically ill patients
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nephrology"
DOI: 10.1007/s40620-021-01060-8
Abstract: The use of chloride-rich crystalloids for resuscitation is associated with acute kidney injury (AKI). We aimed to explore the impact of resuscitation with chloride-rich crystalloids compared to balanced crystalloids on kidney function recovery in patients… read more here.
Keywords: recovery; community acquired; associated community; sepsis associated ... See more keywords
Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.10.008
Abstract: Sepsis-associated encephalopathy (SAE) is a significant clinical issue that is associated with increased mortality and cost of health care. Dexmedetomidine, an α2 adrenoceptor agonist that is used to provide sedation, has been shown to induce… read more here.
Keywords: clp; inflammation; sepsis associated; dexmedetomidine ... See more keywords
Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
Sign Up to like & getrecommendations! Published in 2020 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2020.107087
Abstract: Cytokine storm generates during various systemic acute infections, including sepsis and current pandemic called COVID-19 (severe) causing devastating inflammatory conditions, which include multi-organ failure or multi-organ dysfunction syndrome (MODS) and death of the patient. Toll-like… read more here.
Keywords: toll like; storm; cytokine storm; sepsis associated ... See more keywords
Sepsis‐associated in‐hospital cardiac arrest: Epidemiology, pathophysiology, and potential therapies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Critical Care"
DOI: 10.1016/j.jcrc.2017.03.023
Abstract: Abstract Sepsis‐associated cardiac arrest is a relatively common occurrence with especially poor outcomes. Of the greater than 200,000 in‐hospital cardiac arrests that occur in the United States annually, between 30,000 and 60,000 occur in patients… read more here.
Keywords: cardiac arrest; epidemiology; hospital cardiac; sepsis associated ... See more keywords