Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis
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DOI: 10.1002/advs.202504406
Abstract: The peripheral immune system contributes to the development of sepsis‐induced cardiomyopathy. However, the underlying mechanisms linking central immune cells and neurons to sepsis‐induced cardiomyopathy remain to be clarified. Here, acute sepsis is induced by cecal… read more here.
Keywords: activation; gabaergic neuronal; necroptosis; sepsis induced ... See more keywords
Methylation of miR‐19b‐3p promoter exacerbates inflammatory responses in sepsis‐induced ALI via targeting KLF7
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DOI: 10.1002/cbin.11601
Abstract: Sepsis‐induced acute lung injury is associated with dysregulated inflammatory reactions. MiR‐19b‐3p level was reported to be downregulated in patients with sepsis. To evaluate the role of miR‐19b‐3p in sepsis, cecum ligation and puncture‐induced mouse sepsis… read more here.
Keywords: sepsis; methylation mir; mir 19b; 19b promoter ... See more keywords
Decoding the potential role of regulatory T cells in sepsis‐induced immunosuppression
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DOI: 10.1002/eji.202350730
Abstract: Sepsis, a multiorgan dysfunction with high incidence and mortality, is caused by an imbalanced host‐to‐infection immune response. Organ‐support therapy improves the early survival rate of sepsis patients. In the long term, those who survive the… read more here.
Keywords: regulatory cells; role; induced immunosuppression; sepsis induced ... See more keywords
Clinical value of serum miR‐320‐3p expression in predicting the prognosis of sepsis‐induced acute kidney injury
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DOI: 10.1002/jcla.24358
Abstract: For investigating the expression of miR‐320‐3p in children with sepsis‐induced acute kidney injury (AKI) and its prognostic value. read more here.
Keywords: acute kidney; kidney injury; mir 320; induced acute ... See more keywords
Gut microbiota dysbiosis is associated with sepsis‐induced cardiomyopathy in patients: A case‒control study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28267
Abstract: Myocardial injury is a major complication of sepsis and a key factor affecting prognosis. Therefore, early and accurate diagnosis and timely management of sepsis‐induced cardiomyopathy (SICM) are of great significance for the prevention and treatment… read more here.
Keywords: sepsis; associated sepsis; gut microbiota; induced cardiomyopathy ... See more keywords
Carnosol alleviates sepsis‐induced pulmonary endothelial barrier dysfunction by targeting nuclear factor erythroid2‐related factor 2/sirtuin‐3 signaling pathway to attenuate oxidative damage
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8138
Abstract: Excessive reactive oxygen species production during acute lung injury (ALI) will aggravate the inflammatory process and endothelial barrier dysfunction. Carnosol is a natural phenolic diterpene with antioxidant and anti‐inflammatory properties, but its role in treating… read more here.
Keywords: factor; endothelial barrier; sepsis induced; carnosol ... See more keywords
Isoferulic Acid Mitigates Acute Lung Injury Induced by Sepsis Through the Inhibition of JAK2
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DOI: 10.1002/ptr.8526
Abstract: Sepsis‐induced acute lung injury (ALI), among the most severe organ damages, induces irreversible lung injuries and results in a high mortality rate. The occurrence of ALI is highly correlated with the out‐of‐control inflammatory factors. Therefore,… read more here.
Keywords: pharmacology; jak2; lung injury; ifa ... See more keywords
Inhibition of sepsis‐induced acute kidney injury via the circITCH‐miR‐579‐3p‐ZEB2 axis
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DOI: 10.1002/tox.23682
Abstract: Circular RNAs (circRNAs) are linked to the regulation of sepsis‐induced acute kidney injury (AKI). However, the function of circITCH in the development of sepsis‐induced AKI is still unclear. The levels of circITCH, miR‐579‐3p and ZEB2… read more here.
Keywords: sepsis induced; circitch; 579 zeb2; mir 579 ... See more keywords
Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha
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DOI: 10.1007/s00011-020-01415-0
Abstract: Objective Emerging evidence has revealed that exosomal microRNAs (miRNAs) are implicated in human diseases. However, role of exosomal miR-125b-5p in sepsis-induced acute lung injury (ALI) remains further explored. We focused on the effect of exosomal… read more here.
Keywords: mir 125b; lung; top2a; cell ... See more keywords
iRhom2 deficiency reduces sepsis-induced mortality associated with the attenuation of lung macrophages in mice
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DOI: 10.1007/s00418-024-02318-5
Abstract: Sepsis has a high mortality rate and leads to multi-organ failure, including lung injury. Inactive rhomboid protease family protein (iRhom2) has been identified as accountable for the release of TNF-α, a crucial mediator in the… read more here.
Keywords: sepsis induced; mice; irhom2 deficiency; sepsis ... See more keywords
Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway
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DOI: 10.1007/s10565-025-10007-9
Abstract: Andrographolide (AP) has been shown to possess anti-inflammatory activities. In this study, the impact of AP in sepsis-induced acute liver injury (ALI) and the molecules involved were dissected. FKBP1A was predicted to be the sole… read more here.
Keywords: induced acute; acute liver; notch1 ak2; fkbp1a ... See more keywords