Machine learning and murine models explain failures of clinical sepsis trials
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000003691
Abstract: All sepsis is not the same. There are differences in the inflammatory responses that result from intra-abdominal sepsis and gram-negative pneumonia models. HAT is beneficial in intra-abdominal sepsis but not in the pulmonary sepsis model.… read more here.
Keywords: sepsis; abdominal sepsis; sepsis trials; pna ... See more keywords
The 15th Anniversary of Life—Sepsis Trials
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DOI: 10.3390/life15101517
Abstract: Clinical trials of drugs specifically targeting the sepsis response have frequently produced negative or inconclusive results. This has largely been due to the broad heterogeneity of enrolled patient populations, particularly when inclusion was based on… read more here.
Keywords: 15th anniversary; life sepsis; sepsis trials; life ... See more keywords