Deregulated microRNA-22-3p in patients with sepsis-induced acute kidney injury serves as a new biomarker to predict disease occurrence and 28-day survival outcomes
Sign Up to like & getrecommendations! Published in 2021 at "International Urology and Nephrology"
DOI: 10.1007/s11255-021-02784-z
Abstract: Acute kidney injury (AKI) is a common and serious complication of sepsis. MicroRNA-22-3p (miR-22-3p) has been found to be involved in septic AKI progression. The purpose of this study was to analyze both the serum… read more here.
Keywords: sepsis; aki patients; septic aki; mir ... See more keywords
The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101767
Abstract: Sepsis is the major cause of acute kidney injury (AKI) associated with high mortality rates. Mitochondrial dysfunction contributes to the pathophysiology of septic AKI. Mitophagy is an important mitochondrial quality control mechanism that selectively eliminates… read more here.
Keywords: septic aki; aki; mitophagy; pink1 park2 ... See more keywords
Involvement of phosphatase and tensin homolog-induced putative kinase 1–Parkin-mediated mitophagy in septic acute kidney injury
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000448
Abstract: Abstract Background: Studies have reported mitophagy activation in renal tubular epithelial cells (RTECs) in acute kidney injury (AKI). Phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and E3 ubiquitin-protein ligase Parkin are involved in mitophagy… read more here.
Keywords: septic aki; expression; pink1; acute kidney ... See more keywords
Macrophage Migration Inhibitory Factor Provides a Predictive Performance of Septic Acute Kidney Injury
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DOI: 10.1097/shk.0000000000001918
Abstract: ABSTRACT Background: Septic acute kidney injury (AKI) is a common condition in ICU with poor outcomes. Septic AKI patients have a progressively decreased urine output and increased serum creatinine. However, urine volume and serum creatinine… read more here.
Keywords: aki; acute kidney; serum mif; septic acute ... See more keywords
The Circ_35953 induced by the NF‐κB mediated the septic AKI via targeting miR‐7219‐5p/HOOK3 and IGFBP7 axis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17731
Abstract: A few studies suggested that CircRNAs were involved in the development of septic AKI. However，the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we found that Circ_35953 was induced by LPS… read more here.
Keywords: hook3 igfbp7; circ 35953; mir 7219; septic aki ... See more keywords
How Does Continuous Renal Replacement Therapy Affect Septic Acute Kidney Injury?
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DOI: 10.1159/000492026
Abstract: Sepsis is the leading cause of acute kidney injury (AKI) in the intensive care unit. As the most common treatment of septic AKI, it is believed that continuous renal replacement therapy (CRRT) can not only… read more here.
Keywords: kidney injury; septic aki; crrt; acute kidney ... See more keywords
Molecular differences in susceptibility of the kidney to sepsis-induced kidney injury
Sign Up to like & getrecommendations! Published in 2017 at "BMC Nephrology"
DOI: 10.1186/s12882-017-0602-x
Abstract: BackgroundSeptic acute kidney injury affects 40–50% of all septic patients. Molecular differences between septic patients with and without acute kidney injury (AKI) are only poorly understood. Here, we investigated gene expression changes that differentiated the… read more here.
Keywords: sepsis; kidney injury; septic aki; regulated fold ... See more keywords
Urinary neutrophil gelatinase-associated lipocalin values alone and combined with Prognostic Index predict septic AKI, DIC, and shock: a pilot study
Sign Up to like & getrecommendations! Published in 2020 at "BMC Research Notes"
DOI: 10.1186/s13104-020-05232-w
Abstract: Sepsis is a syndrome involving life-threatening organ dysfunction. The present study aimed to determine whether septic AKI, ARDS, DIC, and shock can be predicted more readily by combining uNGAL values and inflammation-based prognostic scores, over… read more here.
Keywords: septic aki; ungal day; day auc; dic shock ... See more keywords
Incidence, risk factors and clinical outcomes of septic acute renal injury in cancer patients with sepsis admitted to the ICU: A retrospective study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1015735
Abstract: Background The purpose of this study was to clarify the incidence, risk factors, and clinical outcomes of septic acute kidney injury (AKI) in cancer patients with sepsis admitted to the intensive care unit (ICU). Methods… read more here.
Keywords: aki; clinical outcomes; cancer patients; risk factors ... See more keywords
Cul4a attenuates LPS-induced acute kidney injury via blocking NF-κB signaling pathway in sepsis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Biochemistry"
DOI: 10.5937/jomb0-33096
Abstract: Background: Acute kidney injury (AKI) is a common disease that can develop into end-stage kidney disease. Sepsis is one of the main causes of AKI. Currently, there is no satisfactory way to treat septic AKI.… read more here.
Keywords: kidney injury; lps induced; septic aki; cul4a ... See more keywords